1-Cyclohexylpiperazine

September 2026 changed changed 477207479 1-Cyclohexylpiperazine.svg skin-invert-image 200px 1-Cyclohexylpiperazine correct chemspider 78749 1/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2 XPDSXKIDJNKIQY-UHFFFAOYAK N2CCN(C1CCCCC1)CC2 correct EBI 574182 correct chemspider 1S/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2 correct chemspider XPDSXKIDJNKIQY-UHFFFAOYSA-N changed ?? 17766-28-8 correct FDA 2U3UBJ45HD 87298 C1CCC(CC1)N2CCNCC2 10 20 2 1-Cyclohexylpiperazine is a synthetic chemical compound derived from piperazine. As a substituted piperazine, 1-cyclohexylpiperazine serves as a precursor and intermediate for several experimental antineoplastics and substances, including PB-28 and phenoxyalkylpiperazine derivatives.2026-05-17 1-Cyclohexylpiperazine https://www.tcichemicals.com/JP/ja/p/C1783 2026-09-11 TCIBerardi Francesco Abate Carmen Ferorelli Savina Uricchio Vincenzo Colabufo Nicola A. Niso Mauro Perrone Roberto Exploring the Importance of Piperazine N-Atoms for σ 2 Receptor Affinity and Activity in a Series of Analogs of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) Journal of Medicinal Chemistry 10 December 2009 52 23 7817–7828 10.1021/jm9007505 19842660 M Kimura T Masuda K Yamada M Mitani N Kubota N Kawakatsu K Kishii M Inazu Y Kiuchi K Oguchi T Namiki Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter https://hero.epa.gov/reference/11440534/ HERO 3953-3963The Critical Role of Piperazine Derivatives: Focus on 1-Cyclohexylpiperazine https://www.nbinno.com/article/pharmaceutical-intermediates/the-critical-role-of-piperazine-derivatives-focus-on-1-cyclohexylpiperazine-hz 2026-09-17 www.nbinno.com 1-cyclohexylpiperazine is also recognized as an eye and respiratory irritant,C1783_JP_EN.pdf https://www.tcichemicals.com/JP/ja/p/C1783#docomentsSectionPDP https://drive.google.com/file/d/1eb4I5LCh25ViiWJOeyDhOXDG6H-7B6GX/view?usp=sharing 2026-09-11 2026-09-11 TOKYO CHEMICAL INDUSTRY CO., LTD.1-Cyclohexylpiperazine https://pubchem.ncbi.nlm.nih.gov/compound/87298 2026-09-11 PubChem and is potentially corrosive to human skin.ECHA CHEM https://chem.echa.europa.eu/100.037.939/industry/125109 2026-09-15 chem.echa.europa.eu2026-12-05 SAFETY DATA SHEET https://documents.thermofisher.com/DirectWebViewer/private/document.aspx?prd=MAYAC13430~~PDF~~MTR~~AGHS~~EN~~2025-12-20%2018:24:38~~1-Cyclohexylpiperazine~~ 2026-09-15 ThermoFisher SCIENTIFIC In pharmacology, 1-cyclohexylpiperazine, unlike some derived piperazines, is not considered a drug.Rizwan Muhammad Noreen Sobia Asim Sadia Liaqat Zohaib Shaheen Musrat Ibrahim Hina A comprehensive review on the synthesis of substituted piperazine and its novel bio-medicinal applications Chemistry of Inorganic Materials April 2024 2 100041 10.1016/j.cinorg.2024.100041 free It is instead classified as a ligand with an affinity for sigma receptors (σ-receptors).Berardi Francesco Abate Carmen Ferorelli Savina Colabufo Nicola Perrone Roberto 1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review Central Nervous System Agents in Medicinal Chemistry September 2009 9 3 205–219 10.2174/1871524910909030205 20021355 In unsubstituted variants, 1-cyclohexylpiperazine has a weak affinity for sigma-1 and sigma-2 receptors (σ-receptors), though its derivatives have some form of nanomolar affinity.1-Cyclohexylpiperazine (CAS 17766-28-8) API Intermed. BenchChem https://www.benchchem.com/product/b093859#bc-scientific-summary https://archive.org/details/1-cyclohexylpiperazine-cas-17766-28-8-api-intermed.-bench-chem 2026-09-17 2026-09-16 www.benchchem.com Characteristics Properties and molecular structure thumb|A 2D diagram of 1-Cyclohexylpiperazine. Image provided by PubChem.|left|149x149px At standard temperature and pressure, 1-cyclohexylpiperazine is a solid powder with variable color ranging between white, yellow, and brown.GEEL_13430_A0368639.pdf https://documents.thermofisher.com/TFS-Assets/CCG/certificate/Certificate-of-Analysis/GEEL_13430_A0368639.PDF 2026-09-15 ThermoFisher SCIENTIFIC 1-cyclohexylpiperazine has a molecular formula of C10H20N22026-05-17 1-Cyclohexylpiperazine https://www.tcichemicals.com/JP/ja/p/C1783 2026-09-11 TCI1-Cyclohexylpiperazine https://www.sigmaaldrich.com/JP/ja/product/aldrich/75475?srsltid=AfmBOopn_XHI7jSWLjQ1bi8y4Pc-GJOT8b6RL2v0OHzHUCN8Tt0Eh1bg 2026-09-11 MERCK and a molar mass of 168.28 g/mol, or 168.162648646 Da. 1-cyclohexylpiperazine is composed of a piperazine ring, a cyclohexyl group, and aliphatic nitrogen amines. As nitrogen possesses lone pairs of electrons, this leads to the compound's high molecular nucleophilicity and a potential to transfer electrons.Reactions of Piperazines https://www.ambeed.com/further-reading/reactions-of-piperazines.html 2026-09-11 AmBeed As such, 1-cyclohexylpiperazine may react strongly with oxidizing agents during N-oxidation. Its nitrogen atoms may also exist in protonated forms, which supplement the formation of an ionic salt if counterions are present.Alver Özgür Parlak Cemal Vibrational spectroscopic investigation and conformational analysis of 1-cyclohexylpiperazine Journal of Molecular Structure June 2010 975 1–3 85–92 10.1016/j.molstruc.2010.03.090 2010JMoSt.975...85A Physical properties At 25°C (77°F) and 1 standard atmosphere (101.325 kPa) in air, 1-cyclohexylpiperazine possesses a density of 0.9725 g/cm3.1-Cyclohexylpiperazine Documentation Hub BenchChem https://www.benchchem.com/product/B093859/docs#1-cyclohexylpiperazine-cas-number-17766-28-8-characterization 2026-09-17 www.benchchem.com en Furthermore, it retains a low melting point of 28°C (88.2°F) to 37°C (98.6°F), a flash point of 103.3°C (217.94°F)September 2026 and a boiling point of 255.7 (492.26°F) to 287.25°C (549.05°F), assuming 760 mmHg.1-Cyclohexylpiperazine 17766-28-8 https://www.chemicalbook.com/ChemicalProductProperty_EN_CB1309032.htm 2026-09-14 ChemicalBook enMATERIAL SAFETY DATA SHEET SDS/MSDS https://www.cdhfinechemical.com/images/product/msds/37_1819359638_1-Cyclohexylpiperazin-CASNO-17766-28-8-MSDS.pdf https://drive.google.com/file/d/1_sp6TFAFxjGTZrjLrUvelXtpkot6h709/view?usp=sharing 2026-09-14 2026-09-14 CDH As 1-cyclohexylpiperazine is moderately hydrophobic, it is only slightly soluble in water. It is soluble in methanol and chloroform. Safety and precautions Toxicity 1-cyclohexylpiperazine is considered toxic to the human body, specifically the respiratory system. In vaporous forms, it is advised to use in a well-ventilated area, or outdoors. In solid forms, it is ill-advised for consumption. Applications 1-cyclohexylpiperazine serves as a fundamental intermediate, e.g. neuropharmacological derivatives used for the treatment of cranial nerve disorders, or for the synthesis of active pharmaceutical ingredients like Avatrombopag.2026-05-01 1-Cyclohexylpiperazine CAS number 17766-28-8 characterization https://pdf.benchchem.com/93/1_Cyclohexylpiperazine_CAS_number_17766_28_8_characterization.pdf BENCH CHEM 1-12 It may also serve as a negative control and reference standard for nuclear magnetic resonance spectroscopy. References Category:1-Piperazinyl compounds Category:Cyclohexyl compounds