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1-Formyl-LSD
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1F-LSD
1-Formyl-LSD.svg skin-invert-image 175px 1F-LSD 3D.png bg-transparent 250px Oral; Sublingual Serotonergic psychedelic; Hallucinogen None 1-Formyl-LSD; 1-Formyl-N,N-diethyllysergamide; N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide; 1F-LSD N,N-Diethyl-1-formyl-6-methyl-9,10-didehydroergoline-8β-carboxamide 21 25 3 2 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C=O)CC 1S/C21H25N3O2/c1-4-23(5-2)21(26)15-9-17-16-7-6-8-18-20(16)14(12-24(18)13-25)10-19(17)22(3)11-15/h6-9,12-13,15,19H,4-5,10-11H2,1-3H3/t15-,19-/m1/s1 SSEPNHFOVYUBHO-DNVCBOLYSA-N
1-Formyl-LSD, also known as 1-formyl-N,N-diethyllysergamide and sometimes referred to as 1F-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). 1F-LSD АИПСИН https://aipsin.com/newsubstance/584/ ru 26 July 2025 Catalani V, Arillotta D, Corkery JM, Guirguis A, Vento A, Schifano F Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach Frontiers in Psychiatry 11 9 February 2021 632405 33633599 10.3389/fpsyt.2020.632405 1664-0640 free 7900492 It is the 1-formyl derivative of LSD.
Another drug, 1‐(furan‐2‐carbonyl)‐LSD (SYN-L-005), has also been referred to as "1F-LSD". Brandt SD, Kavanagh PV, Gare S, Elliott SP, Stratford A, Halberstadt AL Analytical and Pharmacological Characterization of 1-(Furan-2-Carbonyl)-LSD (1F-LSD) and Comparison With 1-(Thiophene-2-Carbonyl)-LSD (1T-LSD) Drug Testing and Analysis 3 December 2024 17 8 1283–1293 39624022 10.1002/dta.3829 1942-7603 free 12319525
Use and effects
LSD#Uses LSD#Effects
The drug is assumed to act as a prodrug of LSD. It produces psychedelic effects in humans similarly to LSD. Effective doses have been reported to be 100 to 150μg orally or sublingually. Very little is known about the pharmacology and properties of 1-formyl-LSD.
Interactions
Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes
History
1-Formyl-LSD was first described in the scientific literature by 2021. It first emerged as a novel designer drug online in January 2019.
Society and culture
Legal status
Canada
1-Formyl-LSD is not an explicitly nor implicitly controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada 5 December 2025 https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 20 January 2026
United States
1-Formyl-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
See also
Substituted lysergamide
Lizard Labs
References
External links
1-Formyl-LSD - Isomer Design
1F-LSD?? - Bluelight
Category:Designer prodrugs
Category:Diethylamides
Category:Formyl compounds
Category:LSD
Category:Psychedelic lysergamides