(RS)-norcoclaurine 6-O-methyltransferase

Class of enzymes (RS)-norcoclaurine 6-O-methyltransferase 2.1.1.128 167398-06-3 0030786 In enzymology, (RS)-norcoclaurine 6-O-methyltransferase (2.1.1.128) is an enzyme that catalyzes the chemical reaction:Rueffer M, Nagakura N, Zenk MH 1983 Partial purification and properties of S-adenosyl-L-methionine:(R),(S)-norlaudanosoline-6-O-methyltransferase from Argemone platyceras cell cultures Planta Med. 49 131–137 10.1055/s-2007-969833 17405035 11 1983PlMed..49..131R Sato F, Tsujita T, Katagiri Y, Yoshida S, Yamada Y 1994 Purification and characterization of S-adenosyl-L-methionine: norcoclaurine 6-O-methyltransferase from cultured Coptis japonica cells Eur. J. Biochem. 225 125–31 7925429 10.1111/j.1432-1033.1994.00125.x 1 free Stadler R, Zenk MH 1990 A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline Liebigs Ann. Chem. 555–562 10.1002/jlac.1990199001104 60% Q27102564 (S)-norcoclaurine + SAM coclaurine + SAH In this methylation reaction, the enzyme uses the cofactor, S-adenosyl methionine (SAM) which transfers a methyl group, giving S-adenosyl-L-homocysteine (SAH) as a by-product. As the name of the enzyme implies, it also converts (R)-norclaurine to (R)-coclaurine.2.1.1.128Tian Ya Kong Lingzhe Li Qi Wang Yifan Wang Yongmiao An Zhoujie Ma Yuwei Tian Lixia Duan Baozhong Sun Wei Gao Ranran Chen Shilin Xu Zhichao Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids Natural Product Reports 2024 41 11 1787–1810 10.1039/d4np00029c 39360417 Family This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase. This enzyme participates in alkaloid biosynthesis. References Biology no Category:EC 2.1.1 Category:Enzymes of unknown structure