2-hydroxy-3-oxopropionate reductase

InterPro Family 2-hydroxy-3-oxopropionate reductase 1.1.1.60 9028-68-6 0008679 In enzymology, a 2-hydroxy-3-oxopropionate reductase (1.1.1.60) is an enzyme that catalyzes the chemical reaction 50% Q27104217 D-glyceric acid + NAD+ reversible H+ H+ Q15732146 2-hydroxy-3-oxopropanoic acid + NADH The two substrates of this enzyme are D-glyceric acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-hydroxy-3-oxopropanoate, reduced NADH, and a proton. The enzyme can alternatively use nicotinamide adenine dinucleotide phosphate as its cofactor.1.1.1.60Gotto AM, Kornberg HL 1961 The metabolism of C2 compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase Biochem. J. 81 273–84 13900766 1243334 2 10.1042/bj0810273 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-glycerate:NAD(P)+ oxidoreductase. This enzyme is also called tartronate semialdehyde reductase. This enzyme participates in glyoxylate and dicarboxylate metabolism. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1YB4. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Enzymes of known structure