2-hydroxy-3-oxoadipate synthase

Class of enzymes 2-hydroxy-3-oxoadipate synthase 2.2.1.5 9054-72-2 0050439 2-hydroxy-3-oxoadipate synthase (2.2.1.5) is an enzyme that catalyzes the following chemical reaction: 70% α-Ketoglutaric acid + Glyoxylic acid 0.6 CO2 Q27101828 2-Hydroxy-3-oxoadipic acid The two substrates of this enzyme are α-ketoglutaric acid and glyoxylic acid. Its products are 2-hydroxy-3-oxoadipic acid and carbon dioxide.Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW 1968 Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase Biochemistry 7 333–7 4320439 10.1021/bi00841a042 1 Stewart PR, Quayle JR 1967 The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria Biochem. J. 102 3 885–897 10.1042/bj1020885 16742506 1270340 The product can spontaneously decarboxylate to give 5-hydroxy-4-oxo-pentanoic acid:Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW 1970 Carboligase activity of alpha-ketoglutarate dehydrogenase Biochemistry 9 1148–53 5418712 10.1021/bi00807a015 5 50% 2-Hydroxy-3-oxoadipic acid CO2 Q82249981 5-hydroxy-4-oxo-pentanoic acid This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.2.2.1.5 References Biology no Category:EC 2.2.1 Category:Thiamine enzymes Category:Enzymes of unknown structure