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1-Benzyl-4-piperidone
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1-Benzyl-4-piperidone.svg 1-Benzyl-4-piperidone https://pubchem.ncbi.nlm.nih.gov/compound/19220 1-benzylpiperidin-4-one 3612-20-2 491630 18137 222-782-4 19220 399249PH5B 1S/C12H15NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2 SJZKULRDWHPHGG-UHFFFAOYSA-N C1CN(CCC1=O)CC2=CC=CC=C2
12 15 1 1 12 g/L (20 °C) water
1-Benzyl-4-piperidone, also called N-benzyl-4-piperidone, is a derivative of 4-piperidone.
Physical properties
1-Benzyl-4-piperidone is normally in liquid state with a yellow color.1-Benzyl-4-piperidone - Hazardous Agents Haz-Map https://haz-map.com/Agents/19321 2026-01-07 haz-map.com It also has a strong odor. Additionally, 1-benzyl-4-piperidone has a solubility of 12 g/L in water at room temperature.SAFETY DATA SHEET https://www.fishersci.com/store/msds?partNumber=AC106132500&countryCode=US&language=en ThermoFisher Scientific
Pharmaceutical chemistry usage
Like the related compound 4-piperidone, 1-benzyl-4-piperidone can be used in the synthesis of fentanyl. While using 1-benzyl-4-piperidone as the starting precursor initially yields benzylfentanyl (which is considered as virtually inactive), the resulting compound can be converted to fentanyl, according to Paul Jassen's works.Stanton Joseph D. Whitley Penn LaRue Leah Bundy William L. Dawson Eric Huskey Angela 2020-12-01 Fentanyl analog positivity among near-real-time urine drug test results in patients seeking health care https://www.sciencedirect.com/science/article/pii/S0376871620304294 Drug and Alcohol Dependence 217 108264 10.1016/j.drugalcdep.2020.108264 32980789 0376-8716 subscription Vardanyan Ruben S. Hruby Victor J. March 2014 Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications Future Medicinal Chemistry 6 4 385–412 10.4155/fmc.13.215 1756-8927 4137794 24635521
Regulations
As other drug precursors, 1-benzyl-4-piperidone is heavily regulated like its parent chemical. It is for example a compound on the DEA list2023-10-24 Special Surveillance List of Chemicals, Products, Materials and Equipment Used in the Manufacture of Controlled Substances and Listed Chemicals https://www.federalregister.gov/documents/2023/10/24/2023-23478/special-surveillance-list-of-chemicals-products-materials-and-equipment-used-in-the-manufacture-of 2026-01-07 Federal Register en and a Class A precursor under Canada's CDSA law.Branch Legislative Services 2025-11-28 Consolidated federal laws of Canada, Controlled Drugs and Substances Act https://laws-lois.justice.gc.ca/eng/acts/c-38.8/page-14.html#docCont 2026-01-07 laws-lois.justice.gc.ca
References
Category:4-Piperidinones
Category:Benzyl compounds