(butirosin acyl-carrier protein)—L-glutamate ligase

Class of enzymes (butirosin acyl-carrier protein)—L-glutamate ligase 6.2.1.39 (Butirosin acyl-carrier protein)—L-glutamate ligase (6.2.1.39, [BtrI acyl-carrier protein]—L-glutamate ligase, BtrJ) is an enzyme with systematic name (BtrI acyl-carrier protein):L-glutamate ligase (ADP-forming). Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway Chemistry & Biology 12 6 665–75 June 2005 15975512 10.1016/j.chembiol.2005.04.010 free This enzyme catalyses the following chemical reaction (1) ATP + L-glutamate + BtrI acyl-carrier protein ADP + phosphate + L-glutamyl-[BtrI acyl-carrier protein] (2) ATP + L-glutamate + 4-amino butanoyl-[BtrI acyl-carrier protein] ADP + phosphate + 4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] This enzyme catalyses two steps in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family. References External links (butirosin+acyl-carrier+protein)—L-glutamate+ligase Biology no Category:EC 6.2.1