1,1-Dimethylurea

1,1-Dimethylurea.svg N,N-Dimethylurea 598-94-7 correct CAS 11244 11737 I988R763P3 1S/C3H8N2O/c1-5(2)3(4)6/h1-2H3,(H2,4,6) YBBLOADPFWKNGS-UHFFFAOYSA-N CN(C)C(=O)N 3 8 2 1 07 Warning H315 H319 H335 P261 P264 P264+P265 P271 P280 P302+P352 P304+P340 P305+P351+P338 P319 P321 P332+P317 P337+P317 P362+P364 P403+P233 P405 P501 1,3-Dimethylurea 1,1-Dimethylurea (DMU) is a urea derivative used as a polar solvent and a reagent in organic reactions. It is a solid, but forms a eutectic with a low melting point in combination with various hydroxylic additives that can serve as a environmentally sustainable solvent for various chemical reactions. 10.1016/j.tet.2014.11.024 Diversity-oriented approach to spirocycles with indole moiety via Fischer indole cyclization, olefin metathesis and Suzuki–Miyaura cross-coupling reactions 2015 Kotha Sambasivarao Ali Rashid Srinivas Venu Krishna Nimita G. Tetrahedron 71 129–138 10.1002/cctc.201402415 Superparamagnetic CuFeO2 Nanoparticles in Deep Eutectic Solvent: An Efficient and Recyclable Catalytic System for the Synthesis of Imidazo[1,2-a]pyridines 2014 Lu Jun Li Xiao-Tang Ma Er-Qian Mo Li-Ping Zhang Zhan-Hui ChemCatChem 6 10 2854–2859 10.1039/b414515a Low-melting sugar–urea–salt mixtures as solvents for Diels–Alder reactions 2005 Imperato Giovanni Eibler Ernst Niedermaier Julia König Burkhard Chem. Commun. 9 1170–1172 15726181 10.1039/B816551C Organic reactions in low melting mixtures based on carbohydrates and L-carnitine—a comparison 2009 Ilgen Florian König Burkhard Green Chemistry 11 6 848 The unsubstituted nitrogen, as an amine-like region, can serve as a nucleophile for a wide range of reactions, including reaction with acyl halides to form acylureas, 10.1021/jm0498351 Tetramethylcyclopropyl Analogue of a Leading Antiepileptic Drug, Valproic Acid. Synthesis and Evaluation of Anticonvulsant Activity of Its Amide Derivatives 2004 Sobol Eyal Bialer Meir Yagen Boris Journal of Medicinal Chemistry 47 17 4316–4326 15294003 coupling with vinyl halides, 10.1002/ejoc.201403405 Efficient and Selective Palladium-Catalysed C-3 Urea Couplings to 3,5-Dichloro-2(1H)-pyrazinones 2015 Belfrage Anna Karin Gising Johan Svensson Fredrik Åkerblom Eva Sköld Christian Sandström Anja European Journal of Organic Chemistry 5 978–986 and multi-component condensation reaction with aldehydes. 10.13040/IJPSR.0975-8232.9(8).3322-27 2018 International Journal of Pharmaceutical Sciences and Research 9 8 3322–3327 Anis Ahamed Ibrahim A. Arif Meera Moydeen Radhakrishnan Surendra Kumar Akbar Idhayadhulla In-Vitro Antibacterial and Cytotoxicity Evaluation of Some Novel Tetrazole Derivatives free The unsubstituted amide-like portion can undergo oxidative coupling with alkenes to give dihydrooxazoles. 10.1002/anie.201904662 Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation 2019 Wu Fan Alom Nur-E Ariyarathna Jeewani P. Naß Johannes Li Wei Angewandte Chemie International Edition 58 34 11676–11680 31211504 References Category:Ureas Category:Dimethylamino compounds Category:Amide solvents