12alpha-hydroxysteroid dehydrogenase

Class of enzymes 12-alpha-hydroxysteroid dehydrogenase 1.1.1.176 61642-40-8 0047013 In enzymology, 12alpha-hydroxysteroid dehydrogenase (1.1.1.176) is an enzyme that catalyzes the chemical reaction 60% cholic acid + NADP+ reversible H+ H+ Q27101844 12-ketochenodeoxycholic acid + NADPH The two substrates of this enzyme are the bile acid, cholic acid, and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are 12-ketochenodeoxycholic acid, reduced NADPH, and a proton.1.1.1.176MacDonald IA, Mahony DE, Jellet JF, Meier CE 1977 NAD-dependent 3alpha- and 12alpha-hydroxysteroid dehydrogenase activities from Eubacterium lentum ATCC no. 25559 Biochim. Biophys. Acta 489 466–76 201289 3 10.1016/0005-2760(77)90167-9Mahony DE, Meier CE, Macdonald IA, Holdeman LV 1977 Bile salt degradation by nonfermentative clostridia Appl. Environ. Microbiol. 34 419–23 921266 4 10.1128/aem.34.4.419-423.1977 242673 1977ApEnM..34..419M This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12alpha-hydroxy steroid dehydrogenase, 12alpha-hydroxy steroid dehydrogenase, NAD+-dependent 12alpha-hydroxysteroid dehydrogenase, and NADP+-12alpha-hydroxysteroid dehydrogenase. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure