1P-LSD

Chemical compound 1P-LSD.svg skin-invert-image 200px 1P-LSD 3D.png bg-transparent 250px Oral Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen None S8 F2 Unscheduled. NpSG PSA In general Unscheduled, unless that was sold for human consumption, could be sold for medical and research purposes. Unscheduled (may be considered illegal if sold for human consumption as an analog of LSD under the federal analogue act) Unscheduled ~100% Hydrolysis LSD Initial: ~0.2 hours 8–12 hours correct CAS 2349358-81-0 119025985 52085129 correct FDA 23R2G2G79C 1-Propanoyl-lysergic acid diethylamide; 1-Propanoyl-LSD; 1-Propionyl-LSD (6aR,9R)-N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide 23 29 3 2 CCN(CC)C(=O)[C@H]1CN(C)[C@@H]2Cc3cn(C(=O)CC)c4cccc(C2=C1)c34 1S/C23H29N3O2/c1-5-21(27)26-14-15-12-20-18(17-9-8-10-19(26)22(15)17)11-16(13-24(20)4)23(28)25(6-2)7-3/h8-11,14,16,20H,5-7,12-13H2,1-4H3/t16-,20-/m1/s1 JSMQOVGXBIDBIE-OXQOHEQNSA-N 1P-LSD, also known as 1-propionyl-LSD, is a psychedelic drug of the lysergamide family related to LSD. It is an amide derivative of LSD and a homologue of ALD-52 (1A-LSD). The drug originated in 2015 when it appeared as a designer drug sold online.http://www.wedinos.org/resources/downloads/Philtre_Issue_5.pdf Philtre Bulletin Issue 5 WEDINOS March 2015 28 July 2015 It was first synthesized as a legal LSD alternative by Lizard Labs, a Netherlands based research chemical laboratory.https://www.vice.com/en/article/this-is-why-so-many-young-brits-are-taking-so-much-acid-and-ecstasy-892/ Why Young Brits Are Taking So Much LSD and Ecstasy Vice 27 July 2015 11 August 2015 Daly M http://www.kfx.org.uk/resources/NUDlistapr2015.pdf Newer Unregulated Drugs KFx April 2015 13 August 2015https://www.businessinsider.com/new-synthetic-drugs-2015-8 A handful of dangerous new legal drugs has public health experts worried Business Insider UK Speiser M 11 August 2015 13 August 2015http://nsddb.eu/substance/502/ 1P-LSD New Synthetic Drugs Database 2016-01-29 https://web.archive.org/web/20160703170103/http://nsddb.eu/substance/502/ 2016-07-03 dead Palamar JJ, Acosta P, Sherman S, Ompad DC, Cleland CM Self-reported use of novel psychoactive substances among attendees of electronic dance music venues The American Journal of Drug and Alcohol Abuse 42 6 624–632 November 2016 27315522 5093056 10.1080/00952990.2016.1181179 It modifies the LSD molecule by adding a propionyl group to the nitrogen atom of LSD's indole group and is a prodrug of LSD.Jose 15 October 2015 Is 1P-LSD A Prodrug To LSD? https://detect-kit.com/is-1p-lsd-a-prodrug-to-lsd/ dead https://web.archive.org/web/20151015162637/http://detect-kit.com/is-1p-lsd-a-prodrug-to-lsd/ 2015-10-15 15 October 2015 Detect-KitLinda P, Stener A, Cipiciani A, Savelli G January–February 1983 Hydrolysis of amides. Kinetics and mechanism of the basic hydrolysis of N-acylpyrroles, N-acylindoles and N-acylcarbazoles Journal of Heterocyclic Chemistry 20 1 247–248 10.1002/jhet.5570200154 Use and effects LSD#Uses LSD#Effects thumb|left|200px|1P-LSD on blotter paper. The dose range of 1P-LSD is 100 to 200μg, with a typical dose estimate of 150μg. Its duration is about 8 to 12hours for most people. The subjective effects of 1P-LSD are not well-defined in the literature, although they are generally thought to be comparable to those of LSD. Schifano F, Orsolini L, Papanti D, Corkery J Neuropharmacology of New Psychoactive Substances (NPS) NPS: Medical Consequences Associated with Their Intake Current Topics in Behavioral Neurosciences 32 351–380 June 2016 27272067 10.1007/7854_2016_15 978-3-319-52442-9 free 643052237 In a 2020 study, the qualitative effects of 1P-LSD and LSD were similar when measured using visual analog scales. The properties of 1P-LSD have also been assessed in other studies. Coney LD, Maier LJ, Ferris JA, Winstock AR, Barratt MJ Genie in a blotter: A comparative study of LSD and LSD analogues' effects and user profile Hum Psychopharmacol 32 3 May 2017 28517366 10.1002/hup.2599 1959.4/unsworks_59079 free Mallaroni P, Mason NL, Vinckenbosch FR, Ramaekers JG The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides Psychopharmacology (Berl) 239 6 1783–1796 June 2022 35487983 9166850 10.1007/s00213-022-06142-4 Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Pharmacology Like ALD-52 (1A-LSD), 1P-LSD is believed to act as a prodrug for LSD via hydrolysis of the propionyl group. When 1P-LSD is incubated in human serum or liver cells, Wagmann L, Richter LH, Kehl T, Wack F, Bergstrand MP, Brandt SD, Stratford A, Maurer HH, Meyer MR In vitro metabolic fate of nine LSD-based new psychoactive substances and their analytical detectability in different urinary screening procedures Anal Bioanal Chem 411 19 4751–4763 July 2019 30617391 10.1007/s00216-018-1558-9 administered intravenously to rats,6 Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD August 2020 Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD) Neuropharmacology 172 107856 10.1016/j.neuropharm.2019.107856 9191647 31756337 or administered either orally or intravenously to human subjects,Grumann C, Henkel K, Brandt SD, Stratford A, Passie T, Auwärter V August 2020 Pharmacokinetics and subjective effects of 1P-LSD in humans after oral and intravenous administration Drug Testing and Analysis 12 8 1144–1153 10.1002/dta.2821 32415750 free high levels of LSD and relatively low levels of 1P-LSD are quickly detected, demonstrating that 1P-LSD is rapidly hydrolyzed into LSD in vivo following ingestion. Indeed, following intravenous administration in humans 1P-LSD is detectable in serum for no longer than 4 hours, after which it is completely converted to LSD. These findings are supported by the similar duration and behavioral effects of 1P-LSD and LSD in both animal and human experiments. Chemistry Synthesis The chemical synthesis of 1P-LSD has been described in a patent from 2024. WO 2024/028495 Stratford A, Williamson JP Synex Holdings BV Prodrugs of Substituted Ergolines https://patents.google.com/patent/WO2024028495A1/ 8 February 2024 Properties The chemical stability of 1P-LSD has been studied. Grumann C, Henkel K, Stratford A, Hermanns-Clausen M, Passie T, Brandt SD, Auwärter V Validation of an LC-MS/MS method for the quantitative analysis of 1P-LSD and its tentative metabolite LSD in fortified urine and serum samples including stability tests for 1P-LSD under different storage conditions J Pharm Biomed Anal 174 270–276 September 2019 31181490 10.1016/j.jpba.2019.05.062 Zhang SH, Tang AS, Chin RS, Goh JY, Ong MC, Lim WJ, Yap AT, So CW Stability studies of ALD-52 and its homologue 1P-LSD J Forensic Sci 68 3 1009–1019 May 2023 36779453 10.1111/1556-4029.15224 Analogues Related compounds include 1cP-LSD, 1B-LSD, 1D-LSD, 1V-LSD, ALD-52 (1A-LSD), 1cP-AL-LAD, AL-LAD, ETH-LAD, 1P-ETH-LAD, PRO-LAD, LSM-775, and LSZ, among others. History 1P-LSD was first described as well as encountered as a novel designer drug in 2015.https://isomerdesign.com/bitnest/external/EMCDDA/New-Drugs-In-Europe-2015 EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA isomerdesign.comN-Пропионил-ЛСД (1P-LSD) АИПСИН https://aipsin.com/newsubstance/182/ ru 2 January 2026N-Пропионил-ЛСД АИПСИН https://aipsin.com/newsubstance/572/ ru 2 January 2026 Society and culture Legal status 1P-LSD is unscheduled in the United States Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf and Canada, but may be considered illegal if sold or used for human consumption as an analogue of LSD under the Federal Analogue Act in the United States. Brandt SD, Kavanagh PV, Westphal F, Stratford A, Elliott SP, Hoang K, Wallach J, Halberstadt AL 6 Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD) Drug Testing and Analysis 8 9 891–902 September 2016 26456305 4829483 10.1002/dta.1884 1P-LSD is a prohibited or controlled substance in Australia, France,20 May 2021 Arrêté du 20 mai 2021 modifiant l'arrêté du 22 février 1990 fixant la liste des substances classées comme stupéfiants https://www.legifrance.gouv.fr/jorf/id/JORFTEXT000043523554 www.legifrance.gouv.fr fr Finland,Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista annetun valtioneuvoston asetuksen liitteen muuttamisesta Government decree amending the annex to the government decree on psychoactive substances prohibited on the consumer market Finnish https://www.finlex.fi/fi/lainsaadanto/saadoskokoelma/2018/840 Denmark,http://laegemiddelstyrelsen.dk/en/licensing/company-authorisations-and-registrations/euphoriant-substances/lists-of-substances Lists of euphoriant substances The Danish Medicines Agency September 2015 Germany,Verordnung zur Änderung der Anlage des Neue-psychoaktive-. Stoffe-Gesetzes und von Anlagen des Betäubungsmittelgesetzes Regulation amending the Annex to the New Psychoactive Substances Act and Appendices to the Narcotics Act German https://www.bgbl.de/xaver/bgbl/start.xav#__bgbl__%2F%2F*%5B%40attr_id%3D%27bgbl119s1083.pdf%27%5D__1563358129436 Estonia,https://www.sam.ee/en/node/10831 Muudatus narkootiliste ja psühhotroopsete ainete I nimekirjas Republic of Estonia Agency of Medicines Estonian 2019-02-04 2019-04-25 https://web.archive.org/web/20190425061119/https://www.sam.ee/en/node/10831 dead Japan,http://www.mhlw.go.jp/seisakunitsuite/bunya/kenkou_iryou/iyakuhin/yakubuturanyou/dl/meisho.pdf 指定薬物一覧 Ministry of Health, Labour and Welfare Japanese Latvia,http://likumi.lv/doc.php?id=121086 Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem Latvijas Republikas tiesību akti Latvian Norway,https://lovdata.no/dokument/SF/forskrift/2013-02-14-199 31 Forskrift om narkotika (narkotikaforskriften) Helse- og omsorgsdepartementet Norwegian 14 February 2013 Romania,Legea 194/2011 privind combaterea operatiunilor cu produse susceptibile de a avea efecte psihoactive, altele decat cele prevazute de acte normative in vigoare, republicata 2014 http://www.dreptonline.ro/legislatie/legea_194_2011_combaterea_operatiunilor_produse_susceptibile_efecte_psihoactive.php 2020-07-24 www.dreptonline.ro Sweden,Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor Ordinance (1999: 58) on the prohibition of certain dangerous goods Swedish https://notisum.se/rnp/sls/sfs/20150997.pdf Switzerland,https://www.admin.ch/opc/de/classified-compilation/20101220/index.html Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien Der Bundesrat German United Kingdom,Psychoactive Substances Act 2016 https://www.legislation.gov.uk/ukpga/2016/2/contents 28 November 2023 legislation.gov.uk Italy,https://www.gazzettaufficiale.it/eli/id/2021/10/18/21A06118/sg Gazzetta Ufficiale www.gazzettaufficiale.it Singapore,Misuse of Drugs Act - Singapore Statutes Online https://sso.agc.gov.sg/Act/MDA1973 sso.agc.gov.sg the Czech Republic,https://www.zakonyprolidi.cz/cs/2013-463 Nařízení vlády č. 463/2013 Sb. Nařízení vlády o seznamech návykových látek Zákony pro lidi Czech 2020-03-06 2023-02-07 https://web.archive.org/web/20230207101535/https://www.zakonyprolidi.cz/cs/2013-463 dead and Croatia.Popis droga, psihotropnih tvari i biljaka iz kojih se može dobiti droga te tvari koje se mogu uporabiti za izradu droga https://narodne-novine.nn.hr/clanci/sluzbeni/2019_02_13_259.html 2023-01-02 narodne-novine.nn.hr 1P-LSD has been illegal in Russia since 2017 as an LSD derivative.ИЗМЕНЕНИЯ, КОТОРЫЕ ВНОСЯТСЯ В АКТЫ ПРАВИТЕЛЬСТВА РОССИЙСКОЙ ФЕДЕРАЦИИ В СВЯЗИ С СОВЕРШЕНСТВОВАНИЕМ КОНТРОЛЯ ЗА ОБОРОТОМ НАРКОТИЧЕСКИХ СРЕДСТВ И ПСИХОТРОПНЫХ ВЕЩЕСТВ \ КонсультантПлюс https://www.consultant.ru/document/cons_doc_LAW_404473/4347f565328bac46bfd843bc52fef25ac88cd925/#dst100135 2023-02-07 www.consultant.ru See also Substituted lysergamide Lizard Labs 4-AcO-DMT References External links 1P-LSD - Isomer Design 1P-LSD - PsychonautWiki 1P-LSD: Is “Legal Acid” Legit? Is it Safe? - Tripsitter 1P-LSD - Lysergamide Psychedelics - TripSitter 1P-LSD - Psychedelic Science Review Category:5-HT1A agonists Category:5-HT2A agonists Category:5-HT2B agonists Category:5-HT2C agonists Category:Designer prodrugs Category:Diethylamides Category:Lizard Labs Category:Propionate esters Category:Psychedelic lysergamides Category:Serotonin receptor agonists