2-hydroxymuconate-semialdehyde hydrolase

Class of enzymes 2-hydroxymuconate-semialdehyde hydrolase 3.7.1.9 54004-61-4 0018775 In enzymology, 2-hydroxymuconate-semialdehyde hydrolase (3.7.1.9) is an enzyme that catalyzes the chemical reaction 45% 2-Hydroxymuconate semialdehyde reversible H2O HCO2H HCO2H H2O 2-Oxopent-4-enoic acid The two substrates of this enzyme are 2-hydroxymuconate semialdehyde and water. Its products are 2-oxopent-4-enoic acid and formic acid.3.7.1.9Harayama S, Rekik M, Wasserfallen A, Bairoch A 1987 Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids Molecular and General Genetics MGG 210 241–247 10.1007/BF00325689 2 3481421 20302884 Sala-Trepat JM, Evans WC 1971 The meta cleavage of catechol by Azotobacter species 4-Oxalocrotonate pathway European Journal of Biochemistry 20 400–13 4325686 10.1111/j.1432-1033.1971.tb01406.x 3 free This enzyme belongs to the family of hydrolases, specifically those acting on carbon-carbon bonds in ketonic substances. The systematic name of this enzyme class is 2-hydroxymuconate-semialdehyde formylhydrolase. Other names in common use include 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase, 2-hydroxymuconic semialdehyde hydrolase, HMSH, and HOD hydrolase. This enzyme participates in 5 metabolic pathways: benzoate degradation via hydroxylation, toluene and xylene degradation, 1,4-dichlorobenzene degradation, carbazole degradation, and styrene degradation. Structural studies As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1IUN, 1IUO, 1IUP, 1UK6, 1UK7, 1UK8, 1UK9, 1UKA, 1UKB, and 2D0D. References Biology no Category:EC 3.7.1 Category:Enzymes of known structure