1-phosphatidylinositol-4-phosphate 5-kinase

Class of enzymes 1-phosphatidylinositol-4-phosphate 5-kinase 2.7.1.68 104645-76-3 0016308 In enzymology, 1-phosphatidylinositol-4-phosphate 5-kinase (2.7.1.68) is an enzyme that catalyzes the chemical reaction ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 4-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase. Other names in common use include diphosphoinositide kinase, PIP kinase, phosphatidylinositol 4-phosphate kinase, phosphatidylinositol-4-phosphate 5-kinase, and type I PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of the actin cytoskeleton. Structural studies As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1BO1 and 2GK9. References Kai M, Salway JG, Hawthorne JN 1968 The diphosphoinositide kinase of rat brain Biochem. J. 106 791–801 4295336 4 10.1042/bj1060791 1198582 Kai M, Salway JG, Michell RH, Hawthorne JN 1966 The biosynthesis of triphosphoinositide by rat brain in vitro Biochem. Biophys. Res. Commun. 22 370–375 10.1016/0006-291X(66)90655-3 4 1966BBRC...22..370K Rameh LE, Tolias KF, Duckworth BC, Cantley LC 1997 A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Nature 390 192–6 9367159 10.1038/36621 6656 1997Natur.390..192R 4403301 Biology no Category:EC 2.7.1 Category:Enzymes of known structure