1S-LSD

Chemical compound, Novel psychoactive substance analog, LSD prodrug vanc 6 1S-LSD.svg skin-invert-image 250px 1S-LSD 3D.png bg-transparent 200px Oral, Sublingual Serotonergic psychedelic; Hallucinogen None NpSG (Industrial and scientific use only) correct CAS 172875719 correct FDA 1-(3-(Trimethylsilyl)propionyl)-LSD; 1-[3-(Trimethylsilyl)propanoyl]-LSD; (8β)-1-(3-(Trimethylsilyl)propionyl)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide; X-LSD (6aR,9R)-N,N-diethyl-7-methyl-4-(3-trimethylsilylpropanoyl)-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide 26 37 3 2 1 C[Si](CCC(=O)N1C=C2C[C@H]3N(C[C@@H](C=C3C=3C=CC=C1C32)C(=O)N(CC)CC)C)(C)C 1S/C26H37N3O2Si/c1-7-28(8-2)26(31)19-14-21-20-10-9-11-22-25(20)18(15-23(21)27(3)16-19)17-29(22)24(30)12-13-32(4,5)6/h9-11,14,17,19,23H,7-8,12-13,15-16H2,1-6H3/t19-,23-/m1/s1 RYNRSMKGPSUXLC-AUSIDOKSSA-N 1S-LSD, also known as 1-(3-(trimethylsilyl)propionyl)-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).1S-LSD АИПСИН https://aipsin.com/newsubstance/1612/ ru 1 January 20261S-LSD АИПСИН https://aipsin.com/newsubstance/1875/ ru 6 January 2026 It is the trimethylsilyl derivative of 1P-LSD and functions as a prodrug and functional analogue of LSD. WO 2024/028495 Stratford A, Williamson JP Synex Holdings BV Prodrugs of Substituted Ergolines https://patents.google.com/patent/WO2024028495A1/ 8 February 2024 Tanaka R, Kawamura M, Ito M, Kikura-Hanajiri R Identification of two lysergic acid diethylamide analogs, 1-(3-(trimethylsilyl) propionyl) lysergic acid diethylamide (1S-LSD) and 1-(2-thienoyl)-6-allyl-nor-d-lysergic acid diethylamide (1T-AL-LAD), in paper sheet products distributed on the internet Forensic Toxicology 43 2 370–376 July 2025 40180768 10.1007/s11419-025-00718-3 1S-LSD was developed in response to legal restrictions on similar compounds, such as 1D-LSD, which were banned in Germany under the NpSG law in June 2024.1S-LSD – the new legal LSD-derivative https://lsd-legal.de/en/1s-lsd-the-new-legal-lsd-derivative/ August 17, 2024 LSD-Legal July 3, 20241D-LSD ban from 14.06.2024 https://acid-berlin.de/en/blogs/guide/1d-lsd-ban August 17, 2024 Acid Berlin June 14, 2024 The compound was introduced as a legal alternative by incorporating a trimethylsilyl group, which is not covered under current NpSG regulations. This chemical modification allows 1S-LSD to be legally sold in Germany as of September 2024. It is typically distributed in its hemi-D-tartrate form, a common format for lysergamides due to its stability and ease of use. Use and effects LSD#Uses LSD#Effects The dose of 1S-LSD is reported to be similar to that of LSD. Blotter tabs containing 129μg 1S-LSD have been encountered. 1S-LSD is thought to be a prodrug and produces similar effects as LSD and other LSD prodrugs. Interactions Psychedelic drug#Interactions Trip killer#Serotonergic psychedelic antidotes Pharmacology Pharmacodynamics While specific studies on 1S-LSD are limited due to its recent introduction, it is presumed to share pharmacological properties with LSD and its analogues. These substances typically act as partial agonists at serotonin receptors, particularly the serotonin 5-HT2A receptor, which is responsible for their hallucinogenic effects. The addition of the trimethylsilyl group in 1S-LSD is thought to slightly alter its binding affinity and metabolic profile, although empirical data is still needed.LSD and Its Structural Derivatives https://www.caymanchem.com/news/lsd-and-its-structural-derivatives August 17, 2024 Cayman Chemical August 2024 Chemistry 1S-LSD belongs to the lysergamide class of compounds, which are characterized by the ergoline structure derived from lysergic acid. The compound is closely related to LSD and 1P-LSD but differs by the addition of a trimethylsilyl group on the propionyl chain. The nitrogen atom in the polycyclic indole group of the ergoline structure is a common site for chemical modifications, as it is highly reactive and accessible for various reactions. These modifications often include alkylations, acylations, Mannich reactions, and Michael additions. Such alterations are frequently explored in the synthesis of new analogues to modify pharmacological properties or evade legal controls. The addition of the trimethylsilyl group in 1S-LSD represents a strategic modification designed to keep the substance outside the coverage of Germany's New Psychoactive Substances Act (NpSG). Despite these changes, 1S-LSD likely retains a pharmacological profile similar to that of LSD, acting primarily as a serotonergic hallucinogen.Towards Asymmetric Mannich Reactions and Alkylation of Indoles https://scholarship.richmond.edu/honors-theses/1633/ August 17, 2024 Honors Theses April 22, 2022 Bicalho B Enantioselective Organocatalytic Indole Alkylations Macmillan Research Publications 2021 https://macmillan.princeton.edu/ August 17, 2024Michael Additions and Related Reactions https://s1.lite.msu.edu August 17, 2024 Michigan State University Analogues Analogues of 1S-LSD include 1P-LSD, 1D-LSD, 1T-LSD, 1V-LSD, 1cP-LSD, and 1BP-LSD, among others. Society and culture Legal status Canada 1S-LSD is not a controlled substance in Canada as of 2025.Controlled Drugs and Substances Act Department of Justice Canada https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html 19 January 2026 Germany As of August 2024, 1S-LSD remains legal in Germany, primarily due to the fact that its unique silicon-containing structural alteration circumvent the legislative controls imposed by the NpSG law. The legal status of 1S-LSD in Germany is likely subject to change with future amendments to the NpSG, similarly to its previously banned sister compounds 1V-LSD and 1D-LSD. However, it is anticipated that 1S-LSD will remain legal at least until mid-2025. An update on the 21st of November 2025 added 1S-LSD to the "NpSG" made the sale illegal in Germany ("sechste Verordnung zur Änderung der Anlage des Neue-psychoaktive-Stoffe-Gesetzes (NpSG)"). United States 1S-LSD is not an explicitly controlled substance in the United States. Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026) January 2026 U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division United States https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption. Other countries The legal status of 1S-LSD outside of Germany is not well-documented. Given its structural similarity to LSD, it may be considered a controlled substance analogue in jurisdictions like the United States, where laws like the Federal Analogue Act could apply. Potential users and researchers should verify the legal status of 1S-LSD in their respective countries before acquisition or use. See also Substituted lysergamide ADMB-3TMS-PRINACA CUMYL-3TMS-PRINACA Silandrone Lizard Labs References External links 1S-LSD - Isomer Design Category:5-HT1A agonists Category:5-HT2A agonists Category:5-HT2B agonists Category:5-HT2C agonists Category:Designer prodrugs Category:Diethylamides Category:Lizard Labs Category:Psychedelic lysergamides Category:Trimethylsilyl compounds