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(S)-2-hydroxy-fatty-acid dehydrogenase
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Class of enzymes
(S)-2-hydroxy-fatty-acid dehydrogenase 1.1.1.99 37250-33-2 0047050
In enzymology, (S)-2-hydroxy-fatty-acid dehydrogenase (1.1.1.99) is an enzyme that catalyzes the chemical reaction.
60% Q27102840 (S)-2-hydroxystearic acid
+ NAD+
reversible H+ H+
Q27104152 2-oxostearic acid
+ NADH
The two substrates of this enzyme are (S)-2-hydroxystearic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-oxostearic acid, reduced NADH, and a proton.1.1.1.99 Huang WY, Tang J 1970 Carboxyl-terminal sequence of human gastricsin and pepsin J. Biol. Chem. 245 2189–93 4909888 9 10.1016/S0021-9258(18)63137-0 free
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
See also
(R)-2-hydroxy-fatty-acid dehydrogenase which acts on the enantiomer of the hydroxy acid.
References
Biology no
Category:EC 1.1.1
Category:NADH-dependent enzymes
Category:Enzymes of unknown structure