1-acylglycerophosphocholine O-acyltransferase

Class of enzymes 1-acylglycerophosphocholine O-acyltransferase 2.3.1.23 9027-64-9 0047184 In enzymology, a 1-acylglycerophosphocholine O-acyltransferase (2.3.1.23) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine CoA + 1,2-diacyl-sn-glycero-3-phosphocholine Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and 1,2-diacyl-sn-glycero-3-phosphocholine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include lysolecithin acyltransferase, 1-acyl-sn-glycero-3-phosphocholine acyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, lysophosphatide acyltransferase, and lysophosphatidylcholine acyltransferase. This enzyme participates in glycerophospholipid metabolism. References 1 Bell RM, Coleman RA 1980 Enzymes of glycerolipid synthesis in eukaryotes Annu. Rev. Biochem. 49 459–87 6250446 10.1146/annurev.bi.49.070180.002331 Hill EE, Lands WE 1968 Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine Biochim. Biophys. Acta 152 645–8 5661029 3 10.1016/0005-2760(68)90109-4 https://deepblue.lib.umich.edu/bitstream/2027.42/33183/1/0000571.pdf 2027.42/33183 free Miki Y, Hosaka K, Yamashita S, Handa H, Numa S 1977 Acyl-acceptor specificities of 1-acylglycerolphosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase resolved from rat liver microsomes Eur. J. Biochem. 81 433–41 598375 10.1111/j.1432-1033.1977.tb11968.x 3 2433/221697 free van den Bosch H, van Golde LM, Eibl H, van Deenen LL 1967 The acylation of 1-acylglycero-3-phosphorylcholines by rat-liver microsomes Biochim. Biophys. Acta 144 613–23 6078124 3 10.1016/0005-2760(67)90050-1 Biology no Category:EC 2.3.1 Category:Enzymes of unknown structure