(R)-2,3-Dihydroxy-isovalerate

(R)-2,3-Dihydroxy-isovalerate (2R)-2,3-Dihydroxy-3-methylbutanoic acid (R)-2,3-Dihydroxy-isovalerate.svg 19451-56-0 15684 389255 InChI=1S/C5H10O4/c1-5(2,9)3(6)4(7)8/h3,6,9H,1-2H3,(H,7,8)/t3-/m0/s1 JTEYKUFKXGDTEU-VKHMYHEASA-N 440279 CC(C)([C@H](C(=O)O)O)O 5 10 4 (R)-2,3-Dihydroxy-isovalerate, also known as α,β-dihydroxyisovalerate, is an important intermediate in the biosynthesis of branched-chain amino acids, particularly valine, leucine, and isoleucine. (R)-2,3-Dihydroxy-isovalerate https://hmdb.ca/metabolites/HMDB0012141 Human Metabolome Database (HMDB) This organic compound plays a crucial role in several metabolic pathways, including the superpathway of leucine, valine, and isoleucine biosynthesis, as well as pantothenate and coenzyme A (CoA) biosynthesis. It is produced from 3-hydroxy-3-methyl-2-oxobutanoic acid by the enzyme ketol-acid reductoisomerase (EC 1.1.1.86) and is subsequently converted to 2-oxoisovalerate by the enzyme dihydroxy-acid dehydratase (EC 4.2.1.9). References Category:Branched-chain amino acids Category:Alpha hydroxycarboxylic acids