(3-Aminopropyl)triethoxysilane

(3-Aminopropyl)triethoxysilane APTES.svg Structural formula of (3-aminopropyl)triethoxysilane 3-(Triethoxysilyl)propan-1-amine correct CAS 919-30-2 correct FDA L8S6UBW552 13521 12933 CCO[Si](CCCN)(OCC)OCC 1/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3 WYTZZXDRDKSJID-UHFFFAOYAI 1S/C9H23NO3Si/c1-4-11-14(12-5-2,13-6-3)9-7-8-10/h4-10H2,1-3H3 WYTZZXDRDKSJID-UHFFFAOYSA-N 9 23 1 3 1 0.946 g/mLhttp://www.chemicalbook.com/ChemicalProductProperty_EN_CB8686147.htm 3-Aminopropyltriethoxysilane 919-30-2 Chemicalbook.com 2012-08-01 217 -70 External MSDS 3 1 0 05 07 Danger 227 302 313 315 318 280 305+351+338 98 0.8%(V) Lower4.5%(V) Upper 1,780 mg/kg (oral in rats)3.8 g/kg (Dermal exposure in rabbits) (3-Aminopropyl)triethoxysilane (APTES) is an aminosilane frequently used in the process of silanization, the functionalization of surfaces with alkoxysilane molecules. It can also be used for covalent attaching of organic films to metal oxides such as silica and titania. Use with PDMS APTES can be used to covalently bond thermoplastics to poly(dimethylsiloxane) (PDMS).Sunkara V., Park D.K., Hwang H., Chantiwas R., Soper S.A., and Cho Y.K. (2011). Simple room temperature bonding of thermoplastics and poly(dimethylsiloxane). Lab on a Chip, 11(5), 962-965 Thermoplastics are treated with oxygen plasma to functionalize surface molecules, and subsequently coated with an aqueous 1% by volume APTES solution. PDMS is treated with oxygen plasma and placed in contact with the functionalized thermoplastic surface. A stable, covalent bond forms within 2 minutes. Silsesquioxane synthesis Octa(3-aminopropyl)silsesquioxane can be obtained in a one step hydrolytic condensation using APTES and hydrochloric or trifluoromethanesulfonic acid (CF3SO3H).Janeta Mateusz John Łukasz Ejfler Jolanta Szafert Sławomir 2014-11-24 High-Yield Synthesis of Amido-Functionalized Polyoctahedral Oligomeric Silsesquioxanes by Using Acyl Chlorides Chemistry: A European Journal en 20 48 15966–15974 10.1002/chem.201404153 25302846 1521-3765 Use with cell cultures APTES-functionalized surfaces have been shown to be nontoxic to embryonic rat cardiomyocytes in vitro.Natarajan, Growth and Electrophysiological Properties of Rat Embryonic Cardiomyocytes on Hydroxyl- and Carboxyl-Modified Surfaces, J Biomater Sci Polym Ed 2010 Further experimentation is needed to evaluate toxicity to other cell types in extended culture. Toxicity APTES is a toxic compound with an MSDS health hazard score of 3. APTES fumes are destructive to the mucous membranes and the upper respiratory tract, and should be used in a fume hood with gloves. If a fume hood is not available, a face shield and full face respirator must be implemented. The target organs of APTES are nerves, liver and kidney. References Category:Amines Category:Silyl ethers Category:Ethoxy compounds