15α-Hydroxyestradiol

15alpha-hydroxyestradiol.svg skin-invert-image 200px Estra-1,3,5(10)-triene-3,15α,17β-triol (1S,3S,3aS,3bR,9bS,11aS)-11a-Methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthrene-1,3,7-triol 15α-OH-E2; 15α-Hydroxy-17β-estradiol; 3,15α,17β-Trihydroxyestra-1,3,5(10)-triene 570-30-9 87593 59792 1S/C18H24O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)17(18)15(20)9-16(18)21/h3,5,8,13-17,19-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16+,17-,18-/m1/s1 QVQMPLATUBCZMQ-GVLSGGHMSA-N 66418 C[C@]12CC[C@H]3[C@H]([C@@H]1[C@H](C[C@@H]2O)O)CCC4=C3C=CC(=C4)O 18 24 3 15α-Hydroxyestradiol (15α-OH-E2) is an endogenous estrogen which occurs during pregnancy. Lisboa BP, Goebelsmann U, Diczfalusy E Isolation of 15-alpha-hydroxyoestradiol from human pregnancy urine Acta Endocrinol. 54 3 467–72 March 1967 6071364 10.1530/acta.0.0540467 Jirku H, Kadner S, Levitz M Metabolism of 15alpha-hydroxyestradiol in human pregnancy J. Clin. Endocrinol. Metab. 35 4 522–34 October 1972 4559652 10.1210/jcem-35-4-522 Lee AJ, Kosh JW, Conney AH, Zhu BT Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5 J. Pharmacol. Exp. Ther. 298 2 420–32 August 2001 10.1016/S0022-3565(24)29399-X 11454902 It is structurally related to estriol (16α-hydroxyestradiol) and estetrol (15α-hydroxyestriol or 15α,16α-dihydroxyestradiol). References Category:Estranes Category:Estrogens Category:Hormones of the hypothalamus-pituitary-gonad axis Category:Hormones of the pregnant female Category:Hydroxyarenes Category:Diols