(R)-6-hydroxynicotine oxidase

Class of enzymes (R)-6-hydroxynicotine oxidase 1.5.3.6 37233-46-8 0018530 In enzymology, a (R)-6-hydroxynicotine oxidase (1.5.3.6) is an enzyme that catalyzes the chemical reaction (R)-6-hydroxynicotine + H2O + O2 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O2 The 3 substrates of this enzyme are (R)-6-hydroxynicotine, H2O, and O2, whereas its two products are 1-(6-hydroxypyridin-3-yl)-4-(methylamino)butan-1-one and H2O2. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is (R)-6-hydroxynicotine:oxygen oxidoreductase. Other names in common use include D-6-hydroxynicotine oxidase, and 6-hydroxy-D-nicotine oxidase. It employs one cofactor, FAD. Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BVF, 2BVG, and 2BVH. References 1 Bruhmuller M, Mohler H, Decker K 1972 Covalently bound flavin in D-6-hydroxynicotine oxidase from Arthrobacter oxidans. Purification and properties of D-6-hydroxynicotine oxidase Eur. J. Biochem. 29 143–51 4628374 10.1111/j.1432-1033.1972.tb01968.x 1 Decker K, Bleeg H 1965 Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans Biochim. Biophys. Acta 105 313–24 5849820 2 10.1016/s0926-6593(65)80155-2 Biology no Category:EC 1.5.3 Category:Flavoproteins Category:Enzymes of known structure