2,5-dioxovalerate dehydrogenase

Class of enzymes 2,5-dioxovalerate dehydrogenase 1.2.1.26 37250-92-3 0047533 In enzymology, a 2,5-dioxovalerate dehydrogenase (1.2.1.26) is an enzyme that catalyzes the chemical reaction 50% Q27102258 2,5-Dioxopentanoic acid + NADP+ reversible H2O H+ H+ H2O α-Ketoglutaric acid + NADPH The three substrates of this enzyme are 2,5-dioxovalerate (2,5-dioxopentanoic acid), oxidised nicotinamide adenine dinucleotide phosphate (NADP+), and water. Its products are α-ketoglutaric acid, reduced NADPH, and a proton.1.2.1.26 Adams E, Rosso G Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes The Journal of Biological Chemistry 242 8 1802–14 April 1967 10.1016/S0021-9258(18)96073-4 free 6024771 This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism. References Biology no Category:EC 1.2.1 Category:NADPH-dependent enzymes Category:Enzymes of unknown structure