2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2 -D-glucosyltransferase

Class of enzymes 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase 2.4.1.202 122544-56-3 2,4-Dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase (2.4.1.202, uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase, BX8, BX9, benzoxazinoid glucosyltransferase, DIMBOA glucosyltransferase) is an enzyme with systematic name UDP-alpha-D-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-beta-D-glucosyltransferase.2.4.1.202 It catalyses two chemical reactions which allow plants such as maize to store toxic metabolites, DIBOA and DIMBOA as non-toxic glucosides. Bailey BA, Larson RL Hydroxamic Acid glucosyltransferases from maize seedlings Plant Physiology 90 3 1071–6 July 1989 16666853 1061845 10.1104/pp.90.3.1071 von Rad U, Hüttl R, Lottspeich F, Gierl A, Frey M Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize The Plant Journal 28 6 633–42 December 2001 11851909 10.1046/j.1365-313x.2001.01161.x free 60% DIMBOA + UDP-glucose reversible UDP UDP Q27117195 DIMBOA glucoside 1.5 For example, the enzyme interconverts DIMBOA and the (2R) stereoisomer of its glucoside, using UDP-glucose to transfer the added sugar unit. In a similar way, the glucoside of DIBOA (a compound lacking the methoxy group of DIMBOA) is an alternative substrate: 45% DIBOA + UDP-glucose reversible UDP UDP Q27132715 DIBOA glucoside The hydroxamic acids, DIMBOA and DIBOA are used to defend the plants in which they occur from pathogens. Niemeyer HM 1988 Hydroxamic acids (4-hydroxy-1,4-benzoxazin-3-ones), defence chemicals in the gramineae Phytochemistry en 27 11 3349–3358 10.1016/0031-9422(88)80731-3 References External links 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one+2-D-glucosyltransferase Biology no Category:EC 2.4.1