2-Acetylbutyrolactone

2-Acetylbutyrolactone (ABL) is a derivative of γ-butyrolactone that is used as a precursor in organic synthesis, and it is used to identify primary amines through chemical fluorescence. == Preparation == 2-Acetylbutyrolactone can be prepared by a condensation reaction between an ester of acetic acid (such as ethyl acetate) with γ-butyrolactone in an alkaline solution. 2-Acetylbutyrolactone can also be prepared by reacting ethylene oxide with ethyl acetoacetate in alkaline conditions. == Uses == === Spectrofluorimetry === 2-Acetylbutyrolactone itself is only slightly fluorescent, but its derivatives show high UV fluorescence. The carbonyl group readily reacts with amines to form Schiff bases. It is for this reason that 2-acetylbutyrolactone is frequently used to confirm the creation of amines during organic synthesis. 2-Acetylbutyrolactone can also undergo a Japp–Klingemann reaction to form fluorescent molecules with arylamines. === Drug precursor === Uses of 2-Acetylbutyrolactone also includes synthesis of (alphabetical order): Barmastine Coffee furanone Clomethiazole Cyclopropyl methyl ketone (anti-balding). Also used in recent tebuconazole patents. Although not actually a drug, c-PrAc is also used in the synthesis of Syntin, a rocket propellant fuel. ID-4708 [42048-72-6] Metrenperone Morocromen (Ex 35) Novoldiamine (1-Diethylamino-4-aminopentane) [140-80-7] Ocaperidone Paliperidone Pirenperone Risperidone Ritanserin R 59-022 [93076-89-2] Santalene Seganserin Setoperone α-methylene-γ-butyrolactones. == References ==