1-Aminomethyl-5-methoxyindane

Chemical compound vanc 6 changed changed 477343237 AMMI AMMI structure.svg skin-invert-image 235px Uncontrolled Selective serotonin releasing agent (SSRA); Possible entactogen None changed ?? 1415750-28-5 (hydrochloride) 691876-69-4 correct FDA 585V6BDH9X 45091234 correct chemspider 24205063 AMMI (5-Methoxy-2,3-dihydro-1H-inden-1-yl)methanamine 11 15 1 1 NCC1CCc2c1ccc(OC)c2 correct chemspider 1S/C11H15NO/c1-13-10-4-5-11-8(6-10)2-3-9(11)7-12/h4-6,9H,2-3,7,12H2,1H3 correct chemspider WPBKCMLYKMDWRD-UHFFFAOYSA-N 1-Aminomethyl-5-methoxyindane (AMMI), is a drug developed by a team led by David E. Nichols at Purdue University, which acts as a selective serotonin releasing agent (SSRA) and binds to the serotonin transporter (SERT) with similar affinity relative to DFMDA (Ki = 2,000nM). Trachsel D, Lehmann D, Enzensperger C 2013 Phenethylamine: von der Struktur zur Funktion de Nachtschatten-Verlag 1 978-3-03788-700-4 https://books.google.com/books?id=-Us1kgEACAAJ 21 August 2025 https://archive.org/details/phenethylamine-von-der-struktur-zur-funktion-trachsel-lehmann-enzensperger-2013 Phenethylamines: From Structure to Function Solothurn Nachtschatten-Science 858805226 Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL February 2004 Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters The Journal of Pharmacology and Experimental Therapeutics 308 2 679–687 10.1124/jpet.103.057836 14593087 6439942 Walline CC, Nichols DE, Carroll FI, Barker EL Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition The Journal of Pharmacology and Experimental Therapeutics 325 3 791–800 June 2008 18354055 2637348 10.1124/jpet.108.136200 See also Cyclized phenethylamine 1-Aminomethylindane (1-AMI) 2CB-Ind 1-Aminomethyl-6-methoxytetralin (AMMT) para-Methoxyamphetamine (PMA) References External links AMMI - Isomer Design Category:1-Aminomethylindanes Category:David E. Nichols Category:Entactogens Category:Methoxyphenethylamines Category:Phenol ethers Category:Serotonin releasing agents