1-Deoxy-D-xylulose 5-phosphate

{{DISPLAYTITLE:1-Deoxy-D-xylulose 5-phosphate}} vanc 6 changed 477199225 1-Deoxy-d-xylulose 5-phosphate DOXP.png 1-Deoxy-D-xylulose 5-(dihydrogen phosphate) (2R,3S)-2,3-Dihydroxy-4-oxopentyl dihydrogen phosphate DOXP correct chemspider correct EBI 16493 391473 correct kegg C11437 1/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/t4-,5-/m1/s1 AJPADPZSRRUGHI-RFZPGFLSBQ correct chemspider 1S/C5H11O7P/c1-3(6)5(8)4(7)2-12-13(9,10)11/h4-5,7-8H,2H2,1H3,(H2,9,10,11)/t4-,5-/m1/s1 correct chemspider AJPADPZSRRUGHI-RFZPGFLSSA-N 190079-18-6 correct CAS correct FDA I4C288B3TN 443201 correct drugbank DB02496 O=P(O)(O)OC[C@@H](O)[C@H](O)C(=O)C 1-deoxy-D-xylulose+5-phosphate C5H11O7P 214.11 1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway. Function The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase.Xiang Song Usunow Gerlinde Lange Gudrun Busch Marco Tong Liang January 2007 Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis Journal of Biological Chemistry en 282 4 2676–2682 10.1074/jbc.M610235200 free The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.Bartee David Freel Meyers Caren L. 2018-07-24 Targeting the Unique Mechanism of Bacterial 1-Deoxy- d -xylulose-5-phosphate Synthase Biochemistry en 57 29 4349–4356 10.1021/acs.biochem.8b00548 29944345 6057799 0006-2960 In addition, the molecule is involved in making thiamine (vitamin B1) and pyridoxol (vitamin B6). The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity. Bartee D, Freel Meyers CL Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism Accounts of Chemical Research 51 10 2546–2555 October 2018 30203647 6309272 10.1021/acs.accounts.8b00321 See also DXP reductoisomerase Terpenoid References Category:Monosaccharide derivatives Category:Organophosphates