(S)-coclaurine-N-methyltransferase

Class of enzymes (S)-coclaurine-N-methyltransferase 2.1.1.140 0030794 In enzymology, (S)-coclaurine-N-methyltransferase (2.1.1.140) is an enzyme that catalyzes the chemical reaction 60% coclaurine + SAM Q27102185 (S)-N-methylcoclaurine + SAH S-adenosyl methionine (SAM) provides the methyl group for alkylation of (S)-coclaurine, which is converted to (S)-N-methylcoclaurine, with S-adenosylhomocysteine (SAH) as a by-product.2.1.1.140 Loeffler S, Deus-Neumann B, Zenk MH 1995 S-Adenosyl-L-methionine: (S)-coclaurine-N-methyltransferase from Tinospora cordifolia Phytochemistry 38 1387–1395 10.1016/0031-9422(94)00813-9 6 1995PChem..38.1387L This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase. This enzyme participates in alkaloid biosynthesis. Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, Ma Y, Tian L, Duan B, Sun W, Gao R, Chen S, Xu Z Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids Natural Product Reports 41 11 1787–1810 November 2024 39360417 10.1039/d4np00029c References Biology no Category:EC 2.1.1 Category:Enzymes of unknown structure