18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase

Class of enzymes 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase 2.1.1.183 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase (2.1.1.183, 18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase. Lafontaine D, Vandenhaute J, Tollervey D The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast Genes & Development 9 20 2470–81 October 1995 7590228 10.1101/gad.9.20.2470 free Lafontaine DL, Preiss T, Tollervey D Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Molecular and Cellular Biology 18 4 2360–70 April 1998 9528805 121492 10.1128/mcb.18.4.2360 Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases Journal of Molecular Biology 391 5 884–93 September 2009 19520088 2753216 10.1016/j.jmb.2009.06.015 Lafontaine D, Delcour J, Glasser AL, Desgrès J, Vandenhaute J The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast Journal of Molecular Biology 241 3 492–7 August 1994 8064863 10.1006/jmbi.1994.1525 O'Farrell HC, Pulicherla N, Desai PM, Rife JP Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution RNA 12 5 725–33 May 2006 16540698 1440906 10.1261/rna.2310406 This enzyme catalyses the following chemical reaction 4 S-adenosyl-L-methionine + adenine1779/adenine1780 in 18S rRNA 4 S-adenosyl-L-homocysteine + N6-dimethyladenine1779/N6-dimethyladenine1780 in 18S rRNA DIM1 is involved in pre-rRNA processing. References External links 18S+rRNA+(adenine1779-N6/adenine1780-N6)-dimethyltransferase Biology no Category:EC 2.1.1