(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

Enzyme (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase 1.13.11.80 4ylh.jpg 270 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase hexamer, Streptomyces toyocaensis (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (1.13.11.80, DpgC) is an enzyme Fielding EN, Widboom PF, Bruner SD Substrate recognition and catalysis by the cofactor-independent dioxygenase DpgC Biochemistry 46 49 13994–4000 December 2007 18004875 10.1021/bi701148b catalyses the following chemical reaction (3,5-dihydroxyphenyl)acetyl-CoA + O2 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA. This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate. References Biology no Category:EC 1.13.11