2-Amino-1,2-dihydronaphthalene

Chemical compound changed 477194296 1,2-dihydronaphthalen-2-amine 2-Aminodilin.png skin-invert-image Uncontrolled Oral changed ?? 79605-60-0 correct FDA VGU4389G8H none 133605 correct chemspider 117856 2-ADN; ADN 10 11 1 c2ccc1c(\C=C/C(N)C1)c2 correct chemspider 1S/C10H11N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-6,10H,7,11H2 correct chemspider SHLZSYAMFQNEOF-UHFFFAOYSA-N 2-Amino-1,2-dihydronapthalene (2-ADN or ADN) is a stimulant drug.Hathaway BA, Nichols DE, Nichols MB, Yim GK A new, potent, conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene Journal of Medicinal Chemistry 25 5 535–538 May 1982 6123601 10.1021/jm00347a011 Oberlender R, Nichols DE 19069907 Structural variation and (+)-amphetamine-like discriminative stimulus properties Pharmacology, Biochemistry, and Behavior 38 3 581–586 March 1991 2068194 10.1016/0091-3057(91)90017-V https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=77437efa02b4a0f688e4038b153ddfafde6da614 subscription It is a rigid analogue of phenylisobutylamine and substitutes for amphetamine in rat drug discrimination tests, although at approximately one-fourth the potency. The drug is closely related to 2-aminotetralin (2-AT; 2-amino-1,2,3,4-tetrahydronaphthalene), which also substitutes for amphetamine, and is about twice as potent as 2-AT in substituting for amphetamine. Other homologous and rigid analogues of amphetamine besides 2-ADN and 2-AT include 2-aminoindane (2-AI), 1-naphthylaminopropane (1-NAP), 2-naphthylaminopropane (2-NAP), 1-phenylpiperazine (1-PP), 6-AB 6-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene, and 7-AB 7-amino-6,7,8,9-tetrahydro-5H-benzocycloheptene. Glennon RA, Young R, Hauck AE, McKenney JD Structure-activity studies on amphetamine analogs using drug discrimination methodology Pharmacol Biochem Behav 21 6 895–901 December 1984 6522418 10.1016/s0091-3057(84)80071-4 See also 2-Naphthylamine References Category:Norepinephrine-dopamine releasing agents Category:Stimulants Category:Dialins