17-Dimethylaminoethylamino-17-demethoxygeldanamycin

changed 477209110 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.png skin-invert-image (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[(Dimethylamino)ethyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate 17-DMAG; Alvespimycin correct chemspider 16744073 changed EBI 65324 1/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1 C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC KUFRQPKVAWMTJO-LMZWQJSEBL correct chemspider 1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1 correct chemspider KUFRQPKVAWMTJO-LMZWQJSESA-N correct FDA 467214-20-6 correct FDA 001L2FE0M3 correct EBI 383824 5288674 32 48 4 8 17-Dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) is a chemical compound which is a semi-synthetic derivative of the antibiotic geldanamycin. WO 2002079167 application Preparation of geldanamycin derivatives for the treatment of cancer 2002 Snader, Kenneth M.; Vishnuvajjala, B. Rao; Hollingshead, Melinda G.; Sausville, Edward A. 10.1016/j.bmcl.2005.08.013 Rastelli, Giulio Tian, Zong-Qiang Wang, Zhan Myles, David Liu, Yaoquan Structure-based design of 7-carbamate analogs of geldanamycin Bioorganic & Medicinal Chemistry Letters 2005 15 22 5016–5021 16165354 11380/304137 free It is being studied for the possibility of treating cancer. 10.2174/1568009033481831 Sausville, E. A. Tomaszewski, J. E. Ivy, P. Clinical development of 17-allylamino, 17-demethoxygeldanamycin Curr. Cancer Drug Targets 2003 3 5 377–83 14529389 https://zenodo.org/record/1235858 References Category:Antibiotics Category:Macrocycles Category:1,4-Benzoquinones Category:Carbamates Category:Lactams Category:Ethers Category:Secondary alcohols Category:Conjugated dienes