2-(acetamidomethylene)succinate hydrolase

Class of enzymes 2-(acetamidomethylene)succinate hydrolase 3.5.1.29 37289-09-1 0047411 2-(acetamidomethylene)succinate hydrolase (3.5.1.29) is an enzyme that catalyzes the chemical reaction 70% Q27101815 2-(acetamidomethylidene)succinic acid 2 H2O NH3 succinic semialdehyde 0.8 + CO2 + acetic acid 0.4 The enzyme characterised from Pseudomonas species hydrolyses 2-(acetamidomethylidene)succinic acid to succinic semialdehyde and acetic acid, with ammonia and carbon dioxide as byproducts. The reaction is part of the breakdown of vitamin B6.Nyns EJ, Zach D, Snell EE 1969 The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid J. Biol. Chem. 244 2601–5 5769993 10 10.1016/S0021-9258(18)83442-1 free Huynh MS, Snell EE 1985 Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases J. Biol. Chem. 260 2379–83 3972793 4 10.1016/S0021-9258(18)89564-3 free McCulloch Kathryn M. Mukherjee Tathagata Begley Tadhg P. Ealick Steven E. Structure Determination and Characterization of the Vitamin B6 Degradative Enzyme ( E )-2-(Acetamidomethylene)succinate Hydrolase, Biochemistry 2010 49 6 1226–1235 10.1021/bi901812p 20099871 2849673 This enzyme is a hydrolase, one acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). This enzyme is also called alpha-(N-acetylaminomethylene)succinic acid hydrolase.3.5.1.29 References Biology no Category:EC 3.5.1 Category:Enzymes of unknown structure