2-dehydropantoate 2-reductase

Class of enzymes 2-dehydropantoate 2-reductase 1.1.1.169 37211-74-8 0008677 In enzymology, 2-dehydropantoate 2-reductase (1.1.1.169) is an enzyme that catalyzes the chemical reaction 50% Q23054703 (R)-pantoic acid + NADP+ reversible H+ H+ ketopantoic acid + NADPH The two substrates of this enzyme are (R)-pantoic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are ketopantoic acid, reduced NADPH, and a proton.1.1.1.169((King HL Jr)), Dyar RE, Wilken DR Aug 10, 1974 Ketopantoyl lactone and ketopantoic acid reductases: Characterization of the reactions and purification of two forms of ketopantoyl lactone reductase J. Biol. Chem. 249 15 4689–4695 10.1016/S0021-9258(19)42375-2 free 4603075 This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis. Structural studies As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP. References Biology no Category:EC 1.1.1 Category:NADPH-dependent enzymes Category:Enzymes of known structure