1-Naphthoic acid

Naphthalene-1-carboxylic acid.svg 180px Naphthalene-1-carboxylic acid 1-Naphthylenecarboxylic acidα-Naphthoic acid 86-55-5 6847 201-681-9 2NIV4O66BH 36466 C14091 28651 1908896 6586 1160 1S/C11H8O2/c12-11(13)10-7-3-5-8-4-1-2-6-9(8)10/h1-7H,(H,12,13) LNETULKMXZVUST-UHFFFAOYSA-N C1=CC=C2C(=C1)C=CC=C2C(=O)O 11 8 2 White solid 161 07 Warning 315 319 335 261 264 271 280 302+352 304+340 305+351+338 312 321 332+313 337+313 362 403+233 405 501 1-Naphthoic acid is an organic compound with the formula C10H7CO2H. It is one of two isomeric monocarboxylic acids of naphthalene, the other one being 2-naphthoic acid. In general the hydroxynaphthoic acids are more widely used than the parent naphthoic acids. Synthesis and reactions 1-Naphthoic acid can be prepared by carboxylation of the Grignard reagent generated from 1-bromonaphthalene.10.15227/orgsyn.011.0080 free α-Naphthoic Acid Organic Syntheses 1931 11 80 Henry Gilman Nina B. St. John F. Schulze. 1-Naphthoic acid is a substrate for C-H activation reactions.10.1021/jo200509m Rhodium-Catalyzed Regioselective Olefination Directed by a Carboxylic Group 2011 Mochida Satoshi Hirano Koji Satoh Tetsuya Miura Masahiro The Journal of Organic Chemistry 76 9 3024–3033 21438629 Catalytic hydrogenation of 1-Naphthoic acid gives 1,2,3,4-Tetrahydro-1-naphthoic acid [1914-65-4]. This is used in the synthesis of Tetryzoline. See also Hydroxynaphthoic acids Classes of synthetic cannabinoids Naphthoylindoles, or 3-(1-naphthoyl)indoles Naphthoylpyrroles, or 3-(1-naphthoyl)pyrroles Natural products containing 1-naphthoic acid moiety Neocarzinostatin (as 2-hydroxy-7-methoxy-5-methyl-1-naphthoate) Azinomycin B (as 3-methoxy-5-methyl-1-naphthoate) References Category:1-Naphthyl compounds Category:Naphthoic acids