1-Hydroxypyrene

1-Hydroxypyrene Structure.svg 250px Chemical structure of 1-hydroxypyrene Pyren-1-ol 5315-79-7 correct CAS correct FDA N2H6O5V707 21387 20100 C1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)O 1/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H BIJNHUAPTJVVNQ-UHFFFAOYAT 1S/C16H10O/c17-14-9-7-12-5-4-10-2-1-3-11-6-8-13(14)16(12)15(10)11/h1-9,17H BIJNHUAPTJVVNQ-UHFFFAOYSA-N 34093 C14519 16 10 1 1-Hydroxypyrene is a human metabolite. It can be found in urine of outdoor workers exposed to air pollution. 10.1038/jes.2012.111 23299300 Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis Journal of Exposure Science and Environmental Epidemiology 24 1 17–26 2013 Ciarrocca Manuela Rosati Maria Valeria Tomei Francesco Capozzella Assuntina Andreozzi Giorgia Tomei Gianfranco Bacaloni Alessandro Casale Teodorico Andrè Jean Claude Fioravanti Mario Cuartas Maria Fernanda Caciari Tiziana free Biochemistry Experiments in pigs show that urinary 1-hydroxypyrene is a metabolite of pyrene, when given orally. 10.3109/00498258309052279 6659544 Identification of 1-hydroxypyrene as a major metabolite of pyrene in pig urine Xenobiotica 13 7 415–20 2009 Keimig S. D Kirby K. W Morgan D. P Keiser J. E Hubert T. D A Mycobacterium sp. strain isolated from mangrove sediments produced 1-hydroxypyrene during the degradation of pyrene. 17089707 2006 Zhong Y Metabolite production in degradation of pyrene alone or in a mixture with another polycyclic aromatic hydrocarbon by Mycobacterium sp Environmental Toxicology and Chemistry 25 11 2853–9 Luan T Zhou H Lan C Tam N. F 10.1897/06-042R.1 2006EnvTC..25.2853Z 23874147 Relationship with smoking Highly significant differences and dose-response relationships with regard to cigarettes smoked per day were found for 2-, 3- and 4-hydroxyphenanthrene and 1-hydroxypyrene, but not for 1-hydroxyphenanthrene. 10.1007/s004200000215 11355291 Urinary monohydroxylated phenanthrenes and hydroxypyrene - the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism International Archives of Occupational and Environmental Health 74 3 177–83 2001 Heudorf U Angerer J 2001IAOEH..74..177H 27836084 References Category:Human metabolites Category:Air pollution Category:Recreational drug metabolites Category:Smoking Category:Pyrenes Category:Hydroxyarenes