2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Class of enzymes 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 2.3.1.117 88086-34-4 0008666 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (2.3.1.117) is an enzyme that catalyzes the chemical reaction 75% Q27105375 (1) + succinyl-CoA H2O Q27104304 (2) 1.2 + coenzyme A The three substrates of this enzyme characterised from Escherichia coli are the (S) enantiomer of 2,3,4,5-tetrahydrodipicolinic acid (1), succinyl-CoA, and water. Its products are (S)-2-succinylamino-6-oxoheptanedioic acid (2) and coenzyme A.Simms SA, Voige WH, Gilvarg C 1984 Purification and characterization of succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase from Escherichia coli J. Biol. Chem. 259 2734–41 6365916 5 10.1016/S0021-9258(17)43207-8 free This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. Other names in common use include tetrahydropicolinate succinylase, tetrahydrodipicolinate N-succinyltransferase, tetrahydrodipicolinate succinyltransferase, succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase, succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate, and N-succinyltransferase. This enzyme participates in lysine biosynthesis.2.3.1.117 Structural studies As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1KGQ, 1KGT, 2TDT, and 3TDT. References Biology no Category:EC 2.3.1 Category:Enzymes of known structure