1,3-Butanediol

vanc 3 1,4-Butanediol changed changed 477205091 1,3-Butanediol.svg skin-invert-image 160px Skeletal formula of 1,3-butanediol correct ?? 1,3-Butanediol-3D-balls.png bg-transparent correct ?? Ball and stick model of 1,3-butanediol (S) 1,3-Butanediol-3D-spacefill.png bg-transparent Spacefill model of 1,3-butanediol (S) correct ?? Butane-1,3-diol 1,3-butylene glycol, butane-1,3-diol, or 1,3-dihydroxybutane; Ketohol 107-88-0 correct CAS correct ?? 6290-03-5 (R) correct ?? 24621-61-2 (S) 7896 637497 (R) 446973 (S) 7608 correct chemspider 553103 correct chemspider (R) 394191 correct chemspider (S) 3XUS85K0RA correct FDA 203-529-7 DB02202 changed drugbank 1,3-Butylene+glycol 52683 changed EBI 1231503 changed EBI changed kegg D10695 EK0440000 1731276 1718944 (R) 1718943 (S) 2409 2493173 (R) 1994384 (S) CC(O)CCO 1S/C4H10O2/c1-4(6)2-3-5/h4-6H,2-3H2,1H3 changed chemspider PUPZLCDOIYMWBV-UHFFFAOYSA-N changed chemspider 4 10 2 Colourless liquid 1.0053 g cm−3 −50 477 to 483 1 kg dm−3 −0.74 8 Pa (at 20 °C) 1.44 −501 kJ mol−1 −2.5022 MJ mol−1 227.2 J K−1 mol−1 exclamation mark WARNING 319 413 305+351+338 1 1 0 108 394 butanediol 1,2-Butanediol 1,4-Butanediol 2,3-Butanediol 2-Methylpentane 1,3-Butanediol (also 1,3-butylene glycol) is an organic compound with the formula C4H10O2 (CH3CH(OH)CH2CH2OH).1,3-Butanediol https://pubchem.ncbi.nlm.nih.gov/compound/7896 PubChem, US National Library of Medicine 30 August 2026 22 August 2026 Human Metabolome Database, The Metabolomics Innovation Centre, Canada Foundation for Innovation Metabocard for 1,3-Butanediol HMDB0031320 2026 30 August 2026 https://hmdb.ca/metabolites/HMDB0031320 It is one of four structural isomers of butanediol.Ullmann's Encyclopedia of Industrial Chemistry Butanediols, Butenediol, and Butynediol 2019 1–12 10.1002/14356007.a04_455.pub2 978-3-527-30673-2 Gräfje H, Körnig W, Weitz H, Reiß W, Steffan G, Diehl H, Bosche H, Schneider K, Kieczka H, Pinkos R With two alcohol functional groups, the molecule is classified as a secondary alcohol and diol. Without the R (or D) designation, it is racemic. It is a colorless, bittersweet, water-soluble liquid. 1,3-Butanediol is commonly used as a deodorizer and as a solvent for additives that flavor foods.1,3-Butylene glycol (1,3-butanediol) https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-172/subpart-H/section-172.712 Part 172.712, Food and Drug Administration, US Code of Federal Regulations 31 August 2026 29 July 2016 In resin manufacturing, it is a chemical intermediate for making polyurethane and polyesters. Synthesis It can be manufactured by the aldol condensation of acetaldehyde, then by catalytic hydrogenation. Hydrogenation of 3-hydroxybutanal gives 1,3-butanediol:10.1002/14356007.a01_321.pub2 Aldehydes, Aliphatic 2008 Kohlpaintner C, Schulte M, Falbe J, Lappe P, Weber J 978-3527306732 CH3CH(OH)CH2CHO + H2 → CH3CH(OH)CH2CH2OH Dehydration of 1,3-butanediol gives 1,3-butadiene: CH3CH(OH)CH2CH2OH → CH2=CH-CH=CH2 + 2H2O Manufactured 1,3-butanediol is flammable. Occurrence 1,3-Butanediol is present in bell peppers (Capsicum annuum). Uses and research It is used as an air freshener, flavor ingredient in foods, animal foods, and in handicrafts. It is recognized as a safe food ingredient in the United States. 1,3-Butanediol is under preliminary research for its potential use in recovery from intense exercise, although its high cost of production is a barrier to general adoption for this purpose.Egan B Acute and Intermittent Exogenous Ketosis to Support Recovery From Exercise and Adaptations to Exercise Training: A Narrative Review Scandinavian Journal of Medicine and Science in Sports 35 11 e70158 November 2025 41231045 12614059 10.1111/sms.70158 It is considered to be a potential oral exogenous ketone agent for treating brain mechanisms influencing weight loss in anorexia nervosa.Micali N, Miletta MC, Clemmensen C, Pappaianni E, Lazeyras F, Cuenoud B, Sandi C Providing alternative fuel for the brain in anorexia nervosa: a review of the literature on ketones and their effects on metabolism and the brain Translational Psychiatry 15 1 412 October 2025 41107257 12534556 10.1038/s41398-025-03591-1 free References Category:Alkanediols