2-oxoaldehyde dehydrogenase (NAD+)

Enzyme 2-oxoaldehyde dehydrogenase (NAD) 1.2.1.23 37250-91-2 0047551 thumb | right | 2-oxoaldehyde dehydrogenase (NAD+) reaction In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (1.2.1.23) is an enzyme that catalyzes the chemical reaction a 2-oxoaldehyde + NAD+ + H2O a 2-oxo acid + NADH + H+ The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+. This enzyme participates in pyruvate metabolism. Nomenclature This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include: alpha-ketoaldehyde dehydrogenase methylglyoxal dehydrogenase NAD+-linked alpha-ketoaldehyde dehydrogenase 2-ketoaldehyde dehydrogenase NAD+-dependent alpha-ketoaldehyde dehydrogenase 2-oxoaldehyde dehydrogenase (NAD+) See also 2-oxoaldehyde dehydrogenase (NADP+) References 1 Monder C 1967 Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate J. Biol. Chem. 242 4603–9 4383524 20 10.1016/S0021-9258(18)99499-8 free Ray M, Ray S 1982 On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase J. Biol. Chem. 257 10571–4 7107626 18 10.1016/S0021-9258(18)33859-6 free Ray S, Ray M 1982 Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate J. Biol. Chem. 257 10566–70 7107625 18 10.1016/S0021-9258(18)33858-4 free Biology no Category:EC 1.2.1 Category:NADH-dependent enzymes Category:Enzymes of unknown structure