1-Arseno-3-phosphoglycerate

Chemical compound thumb|right|upright|Chemical structure of 1-arseno-3-phosphoglycerate 1-Arseno-3-phosphoglycerate is a compound produced by the enzyme glyceraldehyde 3-phosphate dehydrogenase, present in high concentrations in many organisms, from glyceraldehyde 3-phosphate and arsenate in the glycolysis pathway. Byers LD, She HS, Alayoff A Interaction of phosphate analogues with glyceraldehyde-3-phosphate dehydrogenase Biochemistry 18 12 2471–80 June 1979 375973 10.1021/bi00579a006 The compound is unstable and hydrolyzes spontaneously to 3-phosphoglycerate, bypassing the energy producing step of glycolysis. Effects on glycolysis 1-Arseno-3-phosphoglycerate can be derived from the glycolytic pathway via the bonding of Arsenate and glyceraldehyde-3-phosphate, which is catalyzed by glyceraldehyde phosphate dehydrogenase (GAPDH). Chen J, Yoshinaga M, Garbinski LD, Rosen BP Barry P. Rosen Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance Molecular Microbiology 100 6 945–53 June 2016 26991003 4992400 10.1111/mmi.13371 The net production of ATP is zero as a result of the formation of the intermediate, 1-arseno-3-phosphoglycerate, as opposed to the conventional pathway, which produces a net result of two ATP molecules. Byers LD Glyceraldehyde-3-phosphate dehydrogenase from yeast Carbohydrate Metabolism - Part D Methods in Enzymology 89 326–35 1982-01-01 6755173 10.1016/S0076-6879(82)89059-9 978-0-12-181989-7 Glyceraldehyde-3-phosphate + AsO4^3- + NAD+ ->[GAPDH] NADH +H+ + 1-Arseno-3-phosphoglycerate References Category:Glycolysis Category:Arsenates Category:Organophosphates