1-pyrroline-4-hydroxy-2-carboxylate deaminase

Class of enzymes 1-pyrroline-4-hydroxy-2-carboxylate deaminase 3.5.4.22 9054-77-7 0047425 In enzymology, a 1-pyrroline-4-hydroxy-2-carboxylate deaminase (3.5.4.22) is an enzyme that catalyzes the chemical reaction 1-pyrroline-4-hydroxy-2-carboxylate + H2O 2,5-dioxopentanoate + NH3 Thus, the two substrates of this enzyme are 1-pyrroline-4-hydroxy-2-carboxylate and H2O, whereas its two products are 2,5-dioxopentanoate and NH3. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing). This enzyme is also called HPC deaminase. This enzyme participates in arginine and proline metabolism. References 1 Singh RM, Adams E Enzymatic deamination of delta-1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (alpha-ketoglutaric semialdehyde) The Journal of Biological Chemistry 240 11 4344–51 1965 10.1016/S0021-9258(18)97067-5 free 5845838 Singh RM, Adams E Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline The Journal of Biological Chemistry 240 11 4352–6 Nov 1965 10.1016/S0021-9258(18)97068-7 free 5845839 Biology no Category:EC 3.5.4 Category:Enzymes of unknown structure