2'-5'-oligoadenylate synthase

OAS1_C 2'-5'-oligoadenylate synthetase Pig 2'-5'-oligoadenylate synthase PDB=1px5.png Pig 2'-5'-oligoadenylate synthetase, N- and C-terminal domains coloured red and blue, respectively. 1PX5 PF10421 IPR018952 In molecular biology, 2'-5'-oligoadenylate synthetase (2-5A synthetase) is an enzyme (2.7.7.84) that reacts to interferon signal. It is an antiviral enzyme that counteracts viral attack by degrading RNAs, both viral and host. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'-5'-oligoadenylates, which activate latent ribonuclease (RNase-L), resulting in degradation of viral RNA and inhibition of virus replication.Ghosh SK, Kusari J, Bandyopadhyay SK, Samanta H, Kumar R, Sen GC Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships J. Biol. Chem. 266 23 15293–9 August 1991 1651324 The C-terminal half of 2'-5'-oligoadenylate synthetase, also referred to as domain 2 of the enzyme, is largely alpha-helical and homologous to a tandem ubiquitin repeat. It carries the region of enzymatic activity betweenApril 2021 at the extreme C-terminal end.Hartmann R, Justesen J, Sarkar SN, Sen GC, Yee VC Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase Mol. Cell 12 5 1173–85 November 2003 14636576 10.1016/S1097-2765(03)00433-7 free Human proteins OAS1 OAS2 OAS3 See also OASL References IPR018952 Category:Protein domains