1-acylglycerol-3-phosphate O-acyltransferase

Class of enzymes 1-acylglycerol-3-phosphate O-acyltransferase 2.3.1.51 51901-16-7 0003841 In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (2.3.1.51) is an enzyme that catalyzes the chemical reaction acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism. References 30em 10.1111/j.1432-1033.1983.tb07096.x Frentzen M, Heinz E, McKeon TA, Stumpf PK 1983 Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts Eur. J. Biochem. 129 629–636 6825679 3 free Hill EE, Lands WE 1968 Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine Biochim. Biophys. Acta 152 645–8 5661029 3 10.1016/0005-2760(68)90109-4 https://deepblue.lib.umich.edu/bitstream/2027.42/33183/1/0000571.pdf 2027.42/33183 free Yamashita S, Hosaka K, Numa S 1973 Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes Eur. J. Biochem. 38 25–31 4774123 10.1111/j.1432-1033.1973.tb03028.x 1 free Biology no Category:EC 2.3.1 Category:Enzymes of unknown structure