16S rRNA (adenine1408-N1)-methyltransferase

Class of enzymes 16S rRNA (adenine1408-N1)-methyltransferase 2.1.1.180 16S rRNA (adenine1408-N1)-methyltransferase (2.1.1.180, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase. Beauclerk AA, Cundliffe E Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides Journal of Molecular Biology 193 4 661–71 February 1987 2441068 10.1016/0022-2836(87)90349-4 Koscinski L, Feder M, Bujnicki JM Identification of a missing sequence and functionally important residues of 16S rRNA:m(1)A1408 methyltransferase KamB that causes bacterial resistance to aminoglycoside antibiotics Cell Cycle 6 10 1268–71 May 2007 17495534 10.4161/cc.6.10.4231 free Holmes DJ, Drocourt D, Tiraby G, Cundliffe E Cloning of an aminoglycoside-resistance-encoding gene, kamC, from Saccharopolyspora hirsuta: comparison with kamB from Streptomyces tenebrarius Gene 102 1 19–26 June 1991 1840536 10.1016/0378-1119(91)90532-g Wachino J, Shibayama K, Kurokawa H, Kimura K, Yamane K, Suzuki S, Shibata N, Ike Y, Arakawa Y Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides Antimicrobial Agents and Chemotherapy 51 12 4401–9 December 2007 17875999 2168023 10.1128/aac.00926-07 This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + adenine1408 in 16S rRNA S-adenosyl-L-homocysteine + N1-methyladenine1408 in 16S rRNA The enzyme provides a panaminoglycoside resistance through interference with the binding of aminoglycosides. References External links 16S+rRNA+(adenine1408-N1)-methyltransferase Biology no Category:EC 2.1.1