2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

Class of enzymes 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase 4.1.1.97 OHCU_decarbox OHCU decarboxylase structure of ohcu decarboxylase from zebrafish PF09349 IPR018020 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) 4.1.1.97 is an enzyme involved in purine catabolism. It catalyses the decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) into (S)-(+)-allantoin.Ramazzina I, Folli C, Secchi A, Berni R, Percudani R Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes Nat. Chem. Biol. 2 3 144–8 March 2006 16462750 10.1038/nchembio768 13441301 Cendron L, Berni R, Folli C, Ramazzina I, Percudani R, Zanotti G The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation. J Biol Chem 2007 282 25 18182–9 17428786 10.1074/jbc.M701297200 free 11577/1777398 free 60% Q27114162 OCHU CO2 Q27098185 (S)-(+)-allantoin This is the third step of the conversion of uric acid (a purine derivative) to allantoin. Step one is catalysed by urate oxidase and step two is catalysed by hydroxyisourate hydrolase.Kim K, Park J, Rhee S Structural and functional basis for (S)-allantoin formation in the ureide pathway. J Biol Chem 2007 282 32 23457–64 17567580 10.1074/jbc.M703211200 free Todd CD, Tipton PA, Blevins DG, Piedras P, Pineda M, Polacco JC Update on ureide degradation in legumes. J Exp Bot 2006 57 1 5–12 16317038 10.1093/jxb/erj013 free Grove Anne The delicate balance of bacterial purine homeostasis Discover Bacteria 2025 2 14 10.1007/s44351-025-00025-7 free Rodrigues Júlia T. Batista Ana Carolina S. Lima João Paulo M. S. De Magalhães Mariana T. Q. Evolutionary divergence of uric acid catabolic enzymes: Structure–function constraints and genomic innovations across taxa Biophysical Reviews 2026 10.1007/s12551-026-01466-3 free References IPR018020 Category:Protein domains