1-alkenylglycerophosphoethanolamine O-acyltransferase

Class of enzymes In enzymology, a 1-alkenylglycerophosphoethanolamine O-acyltransferase (2.3.1.121) is an enzyme that catalyzes the chemical reaction: acyl-CoA + 1-alkenylglycerophosphoethanolamine CoA + 1-alkenyl-2-acylglycerophosphoethanolamine 1-alkenylglycerophosphoethanolamine O-acyltransferase 2.3.1.121 112445-17-7 0047166 Thus, the two substrates of this enzyme are acyl-CoA and 1-alkenylglycerophosphoethanolamine, whereas its two products are CoA and 1-alkenyl-2-acylglycerophosphoethanolamine. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase. This enzyme participates in ether lipid metabolism. Importance 1-alkenylglycerophosphoethanolamine O-acyltransferase creates certain plasmalogens that carry beneficial effects, such as increasing brain health, cardiovascular function, and preventing chronic inflammation.Curran Colleen S. Remaley Alan T. Torabi-Parizi Parizad 2025-12-01 Plasmalogens as biomarkers and therapeutic targets https://www.jlr.org/article/S0022-2275(25)00188-9/abstract Journal of Lipid Research English 66 12 10.1016/j.jlr.2025.100925 0022-2275 41130295Plasmalogens Integrative Medicine https://www.cirm1.org/plasmalogens/ 2026-07-28 en-US They also have a strong substrate preference for long-chain polyunsaturated fatty acids (PUFAs), like docosahexaenoic acid (DHA). This means that they specifically select omega-3 and omega-6 chains to complete the lipid, which directly enriches the membranes of the brain and retina, since they are essential for visual acuity and cognitive processing.EC 2.3.1.121 https://iubmb.qmul.ac.uk/enzyme/EC2/3/1/121.html 2026-07-28 iubmb.qmul.ac.ukWang Tingting Huynh Kevin Giles Corey Mellett Natalie A Duong Thy Nguyen Anh Lim Wei Ling Florence Smith Alex AT Olshansky Gavriel Cadby Gemma Hung Joseph Hui Jennie Beilby John Watts Gerald F Chatterjee Pratishtha 2022 APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies https://onlinelibrary.wiley.com/doi/abs/10.1002/alz.12538 Alzheimer's & Dementia en 18 11 2151–2166 10.1002/alz.12538 1552-5279 free 9787288 35077012 When this enzyme is functioning well, it also allows cells to remove excess cholesterol, helping protect arterial walls and prevent atherosclerosis.Paul Sudip Smith Adam Alexander T. Culham Kevin Gunawan Kevin A. Weir Jacqueline M. Cinel Michelle A. Jayawardana Kaushala S. Mellett Natalie A. Lee Man K. S. Murphy Andrew J. Lancaster Graeme I. Nestel Paul J. Kingwell Bronwyn A. Meikle Peter J. 2021 Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidemia and inflammation https://pmc.ncbi.nlm.nih.gov/articles/PMC8281607/ Journal of Lipid Research 62 100092 10.1016/j.jlr.2021.100092 1539-7262 8281607 34146594 References 1 Arthur G, Page L, Choy PC 1987 Acylation of 1-alkenylglycerophosphoethanolamine and 1-acylglycerophosphoethanolamine in guinea-pig heart microsomes Biochim. Biophys. Acta 921 259–65 3651487 2 10.1016/0005-2760(87)90026-9 Biology no Category:EC 2.3.1 Category:Enzymes of unknown structure