(tyrosine 3-monooxygenase) kinase

Class of enzymes [tyrosine 3-monooxygenase] kinase 2.7.11.6 103537-12-8 0050369 In enzymology, a [tyrosine 3-monooxygenase] kinase (2.7.11.6) is an enzyme that catalyzes the chemical reaction ATP + [tyrosine-3-monooxygenase] ADP + phospho-[tyrosine-3-monooxygenase] Thus, the two substrates of this enzyme are ATP and tyrosine 3-monooxygenase, whereas its two products are ADP and phospho-(tyrosine-3-monooxygenase). This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[tyrosine-3-monoxygenase] phosphotransferase. Other names in common use include pheochromocytoma tyrosine hydroxylase-associated kinase, STK4, and tyrosine 3-monooxygenase kinase (phosphorylating). This enzyme participates in MAPK signaling pathway and non-small cell lung cancer. References 30em Pigeon D, Drissi-Daoudi R, Gros F, Thibault J 1986 [Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase] Comptes Rendus de l'Académie des Sciences, Série III 302 435–8 2872947 12 Pigeon D, Ferrara P, Gros F, Thibault J 1987 Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase J. Biol. Chem. 262 6155–8 2883182 13 10.1016/S0021-9258(18)45551-2 free Biology no Category:EC 2.7.11 Category:Enzymes of unknown structure