2-Phospho-L-lactate guanylyltransferase

Class of enzymes 2-Phospho-L-lactate guanylyltransferase 2.7.7.68 2-Phospho-L-lactate guanylyltransferase (2.7.7.68, CofC, MJ0887) is an enzyme with systematic name GTP:2-phospho-L-lactate guanylyltransferase.2.7.7.68 This enzyme catalyses the following chemical reaction 70% Q27120589 2-phospho-L-lactic acid 0.7 + guanosine triphosphate PPi Q27126710 L-lactyl-2-diphospho-5'-guanosine 1.4 thumb|Coenzyme F420 The enzyme characterised from methanogenic archaea and Paraburkholderia rhizoxinica combines 2-phospho-L-lactic acid and guanosine triphosphate to give L-lactyl-2-diphospho-5'-guanosine, with pyrophosphate (PPi) as a byproduct. The reaction is part of the biosynthesis of coenzyme F420.Grochowski Laura L. Xu Huimin White Robert H. Identification and Characterization of the 2-Phospho-l-lactate Guanylyltransferase Involved in Coenzyme F420 Biosynthesis Biochemistry 2008 47 9 3033–3037 10.1021/bi702475t 18260642 Braga Daniel Last Daniel Hasan Mahmudul Guo Huijuan Leichnitz Daniel Uzum Zerrin Richter Ingrid Schalk Felix Beemelmanns Christine Hertweck Christian Lackner Gerald 3 Metabolic Pathway Rerouting in Paraburkholderia rhizoxinica Evolved Long-Overlooked Derivatives of Coenzyme F 420 ACS Chemical Biology 2019 14 9 2088–2094 10.1021/acschembio.9b00605 31469543 free Bashiri Ghader Antoney James Jirgis Ehab N. M. Shah Mihir V. Ney Blair Copp Janine Stuteley Stephanie M. Sreebhavan Sreevalsan Palmer Brian Middleditch Martin Tokuriki Nobuhiko Greening Chris Scott Colin Baker Edward N. Jackson Colin J. 3 A revised biosynthetic pathway for the cofactor F420 in prokaryotes Nature Communications 2019 10 1 1558 10.1038/s41467-019-09534-x free 30952857 6450877 Hasan Mahmudul Schulze Sabrina Berndt Leona Palm Gottfried J. Braga Daniel Richter Ingrid Last Daniel Lammers Michael Lackner Gerald 3 Diversification by CofC and Control by CofD Govern Biosynthesis and Evolution of Coenzyme F 420 and Its Derivative 3PG-F 420 mBio 2022 13 1 e03501-21 10.1128/mbio.03501-21 free 35038903 8764529 References External links 2-phospho-L-lactate+guanylyltransferase Biology no Category:EC 2.7.7