2-hydroxyacyl-CoA lyase

Class of enzymes 2-Hydroxyphytanoyl-CoA lyase (technically narrower) 4.1.2.63 GO:0106359 2-Hydroxyacyl-CoA lyase (4.1.2.63) is an enzyme found in the peroxisomes of eukaryotes that catalyzes the following leading-up step of alpha oxidation: a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA 400px It requires thiamine diphosphate (ThDP) as cofactor. In animals The entry is intended to mainly represent the class of enzymes examplified by human HACL1 (gene), which can catalyze both reactions and is found in the peroxisome. It is required for handling phytanic acid.ENZYME - 4.1.2.63 2-hydroxyacyl-CoA lyase https://enzyme.expasy.org/EC/4.1.2.63 enzyme.expasy.org Humans and other mammals have another similar enzymes that only catalyzes reaction (2) and is instead located in the endoplasmic reticulum, HACL2 (gene). This one participates in phytosphingosine degradation.UniProt A1L0T0 https://www.uniprot.org/uniprotkb/A1L0T0/entry UniProt en In fungi Both the baker's yeast and the fission yeast have a Pxp1 gene corresponding to this activity, as annotated on UniProt by sequence similarity (not by experimental characterization of enzyme activity). These two versions are known to appear in the cytoplasm and the peroxisome based on experimental evidence listed in UniProt.P39994 https://www.uniprot.org/uniprotkb/P39994/entry UniProt In plants Both the mouse-ear cress (Arath) and the rice have a HACL gene corresponding to this activity, as annotated on UniProt by sequence similarity (not by experimental characterization of enzyme activity). The Arath version is experimentally detected in the cytoplasm, peroxisome, and plastid.Q9LF46 https://www.uniprot.org/uniprotkb/Q9LF46/entry UniProt In other organisms UniProt reports that the social ameoba Dictyostelium discoideum has a version of this enzyme, as annotated on UniProt by sequence similarity (not by experimental characterization of enzyme activity). References External links 2-hydroxyphytanoyl-coenzyme+A+lyase Biology no Category:EC 4.1.2