2-Hydroxyacylsphingosine 1-beta-galactosyltransferase

Class of enzymes 2-hydroxyacylsphingosine 1-beta-galactosyltransferase 2.4.1.45 37277-54-6 0003851 In enzymology, a 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (2.4.1.45) is an enzyme that catalyzes the chemical reaction UDP-galactose + 2-(2-hydroxyacyl)sphingosine UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine Thus, the two substrates of this enzyme are UDP-galactose and 2-(2-hydroxyacyl)sphingosine, whereas its two products are UDP and 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase. Other names in common use include galactoceramide synthaseShayman James Sphingolipid Biology 2006 Springer Tokyon 978-4-431-34200-7 83–94 10.1007/4-431-34200-1_6 Glucosylceramide and Galactosylceramide Synthase , uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, and UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase. References 1 Basu S, Schultz AM, Basu M, Roseman S 1971 Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain J. Biol. Chem. 246 4272–9 5090043 13 10.1016/S0021-9258(18)62081-2 free Morell P, Radin NS 1969 Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid Biochemistry 8 506–12 5793706 10.1021/bi00830a008 2 Biology no Category:EC 2.4.1 Category:Enzymes of unknown structure