2-hydroxyquinoline 8-monooxygenase

Class of enzymes 2-hydroxyquinoline 8-monooxygenase 1.14.13.61 2-hydroxyquinoline 8-monooxygenase (1.14.13.61) is an enzyme that catalyzes the chemical reaction 60% class=skin-invert-image 2-hydroxyquinoline + NADH + H+ O2 H2O Q74417603 2,8-dihydroxyquinoline 2.5 + NAD+ The four substrates of this enzyme are 2-hydroxyquinoline, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are 2,8-dihydroxyquinoline, oxidised NAD+, and water.1.14.13.61Rosche B, Tshisuaka B, Fetzner S, Lingens F 1995 2-Oxo-1,2-dihydroquinoline 8-monooxygenase, a two-component enzyme system from Pseudomonas putida 86 J. Biol. Chem. 270 17836–42 7629085 10.1074/jbc.270.30.17836 30 free The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is quinolin-2(1H)-one,NADH:oxygen oxidoreductase (8-oxygenating). This enzyme is also called 2-oxo-1,2-dihydroquinoline 8-monooxygenase. It is an iron–sulfur protein. Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1Z01, 1Z02, and 1Z03. References Biology no Category:EC 1.14.13 Category:NADPH-dependent enzymes Category:NADH-dependent enzymes Category:Iron enzymes Category:Enzymes of known structure