2-Fluoroamphetamine

Stimulant designer drug vanc 6 changed changed 477213365 1-(2-Fluorophenyl)propan-2-amine 2-fluoroamphetamine.svg skin-invert-image 200px 2-Fluoroamphetamine molecule ball.png bg-transparent 200px Schedule I NpSG Class A changed ?? 1716-60-5 correct FDA V8Q7K3989D 121531 correct drugbank correct chemspider 108441 9 12 1 1 CC(CC1=CC=CC=C1F)N correct chemspider 1S/C9H12FN/c1-7(11)6-8-4-2-3-5-9(8)10/h2-5,7H,6,11H2,1H3 correct chemspider GDSXNLDTQFFIEU-UHFFFAOYSA-N thumb|1 gram of 2-FA 2-Fluoroamphetamine (2-FA) is a stimulant drug from the amphetamine family which has been sold as a designer drug. Rösner P, Quednow B, Girreser U, Junge T Isomeric fluoro-methoxy-phenylalkylamines: a new series of controlled-substance analogues (designer drugs) Forensic Science International 148 2–3 143–156 March 2005 15639609 10.1016/j.forsciint.2004.05.003 2-Fluoroamphetamine differs from 3-fluoroamphetamine and 4-fluoroamphetamine in the position of the fluorine atom on the aromatic ring, making them positional isomers of one another. The replacement of a hydrogen atom with a fluorine atom in certain compounds to facilitate passage through the blood–brain barrier, as is desirable in central nervous system pharmaceutical agents, is a common practice due to the corresponding increase in lipophilicity granted by this substitution. Smart BE Fluorine substituent effects on bioactivity Journal of Fluorine Chemistry 109 3–11 2001 1 10.1016/s0022-1139(01)00375-x 2001JFluC.109....3S Ismail FM Important fluorinated drugs in experimental and clinical use Journal of Fluorine Chemistry 118 1–2 27–33 2002 10.1016/s0022-1139(02)00201-4 2002JFluC.118...27I Pharmacology Anorexiant dose (amount inhibiting food intake by 50% for 2 hours, given 1 hour earlier) = 15 mg/kg (rat; p.o.). Costa E, Garattini S 1970 Amphetamines and Related Compounds 28 New York Raven Press October 2023 Analgesic dose (50% inhibition of response to tail-clamp) = 20 mg/kg (mouse; i.p.).October 2023 Effect on blood pressure: 0.5 mg/kg (rat; i.v.) produces an increase in BP of 29 mm.October 2023 Toxicology LD50 (mouse; i.p.) = 100 mg/kg.October 2023 Legal status United States The Federal Analogue Act, 21 U.S.C. § 813, is a section of the United States Controlled Substances Act, allowing any chemical "substantially similar" to an illegal drug (in Schedule I or II) to be treated as if it were also in Schedule I or II, but only if it is intended (ref 1) for human consumption. 2-FA may be considered to be an analog of amphetamine, thus falling under the Federal Analog Act, if, as stated above, it is intended for human consumption. China As of October 2015 2-FA is a controlled substance in China.http://www.sfda.gov.cn/WS01/CL0056/130753.html 关于印发《非药用类麻醉药品和精神药品列管办法》的通知 China Food and Drug Administration 27 September 2015 zh 1 October 2015 https://web.archive.org/web/20151001222554/http://www.sfda.gov.cn/WS01/CL0056/130753.html 1 October 2015 dead Finland Scheduled in the "government decree on substances, preparations and plants considered to be narcotic drugs" and is hence illegal.https://www.finlex.fi/fi/lainsaadanto/2008/543 Valtioneuvoston asetus huumausaineina pidettävistä aineista, valmisteista ja kasveista | 543/2008 | Lainsäädäntö | Finlex Finlex.fi June 12, 2026 See also 2-Fluoromethamphetamine 2-Methylamphetamine (2-MA) 2-Methoxymethamphetamine (methoxyphenamine) References Category:Substituted amphetamines Category:2-Fluorophenyl compounds Category:Designer drugs Category:Norepinephrine-dopamine releasing agents