2-methylcitrate dehydratase

Class of enzymes 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) 2-methylcitrate dehydratase 4.2.1.79 80891-26-5 0047547 The enzyme 2-methylcitrate dehydratase (4.2.1.79) catalyzes the chemical reaction (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate (Z)-but-2-ene-1,2,3-tricarboxylate + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming]. Other names in common use include 2-methylcitrate hydro-lyase, PrpD, and 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase. This enzyme participates in propanoate metabolism. Structural studies As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1SZQ. References 1 Aoki H, Tabuchi T 1981 Purification and properties of 2-methylcitrate dehydratase from Yarrowia lipolytica Agric. Biol. Chem. 45 12 2831–2837 10.1271/bbb1961.45.2831 free Brock M, Maerker C, Schutz A, Volker U, Buckel W 2002 Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase Eur. J. Biochem. 269 6184–94 12473114 10.1046/j.1432-1033.2002.03336.x 24 free Biology no Category:EC 4.2.1 Category:Enzymes of known structure